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Synthesis of platinum(II) and palladium(II) complexes with 9,9-dihexyl-4,5-diazafluorene and their in vivo antitumour activity against Hep3B xenografted mice.
Wang, Q-W; Lam, P-L; Wong, R S-M; Cheng, G Y-M; Lam, K-H; Bian, Z-X; Ho, C-L; Feng, Y-H; Gambari, R; Lo, Y-H; Wong, W-Y; Chui, C-H.
Affiliation
  • Wang QW; Institute of Molecular Functional Materials, Department of Chemistry and Partner State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Hong Kong, PR China; Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, PR China; HKBU Inst
  • Lam PL; State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, PR China. Electronic address: tcstacey@polyu.edu.hk.
  • Wong RS; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, PR China.
  • Cheng GY; Faculty of Health Sciences, University of Macau, Macau, PR China.
  • Lam KH; State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, PR China.
  • Bian ZX; Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, PR China. Electronic address: bzxiang@hkbu.edu.hk.
  • Ho CL; Institute of Molecular Functional Materials, Department of Chemistry and Partner State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Hong Kong, PR China; HKBU Institute of Research and Continuing Education, Shenzhen Virtual University Park, Shenzhen, 518057,
  • Feng YH; Department of Applied Physics and Chemistry, University of Taipei, Taipei, 100, Taiwan.
  • Gambari R; Centre of Biotechnology, Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.
  • Lo YH; Department of Applied Physics and Chemistry, University of Taipei, Taipei, 100, Taiwan. Electronic address: yhlo@utaipei.edu.tw.
  • Wong WY; Institute of Molecular Functional Materials, Department of Chemistry and Partner State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Hong Kong, PR China; State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Ko
  • Chui CH; State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, PR China; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, PR China; Clinical Division, School of Chinese Medicine, H
Eur J Med Chem ; 124: 537-543, 2016 Nov 29.
Article in En | MEDLINE | ID: mdl-27598239
ABSTRACT
Two complexes dichloro(9,9-dihexyl-4,5-diazafluorene)platinum(II) (Pt-DHF) and dichloro(9,9-dihexyl-4,5-diazafluorene)palladium(II) (Pd-DHF) were synthesized and their in vivo antitumour activity was investigated using an athymic nude mice model xenografted with human Hep3B carcinoma cells. Pt-DHF- and Pd-DHF-treated groups showed significant tumour growth inhibition (with about 9-fold and 3-fold tumour growth retardation) when compared with the vehicle control group. The liver toxicology effects on the animals of the two compounds were investigated. Pt-DHF and Pd-DHF-treated groups had a lower alanine transaminase and aspartate transaminase values than those of the vehicle treated group as the animals from the vehicle control group had very heavy hepatoma burden. We assume that both complexes could be further investigated as effective antitumour agents and it is worthwhile to study their underlying working mechanism.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organoplatinum Compounds / Palladium / Platinum / Coordination Complexes Limits: Animals / Humans Language: En Journal: Eur J Med Chem Year: 2016 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organoplatinum Compounds / Palladium / Platinum / Coordination Complexes Limits: Animals / Humans Language: En Journal: Eur J Med Chem Year: 2016 Document type: Article