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An emerging opportunistic infection: fatal astrovirus (VA1/HMO-C) encephalitis in a pediatric stem cell transplant recipient.
Lum, Su Han; Turner, Andrew; Guiver, Malcolm; Bonney, Denise; Martland, Timorthy; Davies, Emma; Newbould, Melanie; Brown, Julianne; Morfopoulou, Sofia; Breuer, Judith; Wynn, Robert.
Affiliation
  • Lum SH; Department of Blood and Marrow Transplant, Royal Manchester Children's Hospital, Manchester, UK.
  • Turner A; Clinical Virology Department, Manchester Royal Infirmary, Manchester, UK.
  • Guiver M; Clinical Virology Department, Manchester Royal Infirmary, Manchester, UK.
  • Bonney D; Department of Blood and Marrow Transplant, Royal Manchester Children's Hospital, Manchester, UK.
  • Martland T; Department of Neurology, Royal Manchester Children's Hospital, Manchester, UK.
  • Davies E; Clinical Virology Department, Manchester Royal Infirmary, Manchester, UK.
  • Newbould M; Diagnostic Paediatric Histopathology Service, Royal Manchester Children's Hospital, Manchester, UK.
  • Brown J; Microbiology, Virology and Infection Prevention and Control, Great Ormond Street Hospital for Children, London, UK.
  • Morfopoulou S; Research Department of Infection, Division of Infection and Immunity, University College of London, London, UK.
  • Breuer J; Research Department of Infection, Division of Infection and Immunity, University College of London, London, UK.
  • Wynn R; Department of Blood and Marrow Transplant, Royal Manchester Children's Hospital, Manchester, UK.
Transpl Infect Dis ; 18(6): 960-964, 2016 Dec.
Article in En | MEDLINE | ID: mdl-27632248
ABSTRACT
Neuroinvasive astrovirus (VA1-HMO-C) is an emerging life-threatening infection in immunocompromised hosts. We describe an 8-month-old child who died of VA1/HMO-C encephalitis following bone marrow transplantation. The diagnosis was only made post-mortem using RNA deep sequencing of the brain. Repeat analysis of the post-mortem brain tissue using polymerase chain reaction specific primers for VA1/HMO-C was positive. Astrovirus VA1/HMO-C should be included in the evaluation of patients with similar encephalitis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mamastrovirus / Opportunistic Infections / Leukemia, Myeloid, Acute / Bone Marrow Transplantation / Hematopoietic Stem Cell Transplantation / Encephalitis, Viral / Astroviridae Infections / Transplantation Conditioning / Immunosuppressive Agents Type of study: Etiology_studies Limits: Female / Humans / Infant Language: En Journal: Transpl Infect Dis Journal subject: TRANSPLANTE Year: 2016 Document type: Article Affiliation country: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mamastrovirus / Opportunistic Infections / Leukemia, Myeloid, Acute / Bone Marrow Transplantation / Hematopoietic Stem Cell Transplantation / Encephalitis, Viral / Astroviridae Infections / Transplantation Conditioning / Immunosuppressive Agents Type of study: Etiology_studies Limits: Female / Humans / Infant Language: En Journal: Transpl Infect Dis Journal subject: TRANSPLANTE Year: 2016 Document type: Article Affiliation country: Reino Unido