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AC220 and AraC cause differential inhibitory dynamics in patient-derived M5-AML with FLT3-ITD and, thus, ultimately distinct therapeutic outcomes.
An, Xiaoyu; Liu, Jinping; Wang, Na; Wang, Di; Huang, Liang; Zhang, Likun; Cai, Jie; Wery, Jean-Pierre; Zhou, Demin; Zhou, Jianfeng; Li, Qi-Xiang.
Affiliation
  • An X; Crown Bioscience, Inc., Santa Clara, CA, USA.
  • Liu J; Crown Bioscience, Inc., Santa Clara, CA, USA.
  • Wang N; Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
  • Wang D; Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
  • Huang L; Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
  • Zhang L; Crown Bioscience, Inc., Santa Clara, CA, USA.
  • Cai J; Crown Bioscience, Inc., Santa Clara, CA, USA.
  • Wery JP; Crown Bioscience, Inc., Santa Clara, CA, USA.
  • Zhou D; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China.
  • Zhou J; Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
  • Li QX; Crown Bioscience, Inc., Santa Clara, CA, USA; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China.
Exp Hematol ; 45: 36-44.e2, 2017 Jan.
Article in En | MEDLINE | ID: mdl-27670587
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylurea Compounds / Leukemia, Myeloid, Acute / Gene Duplication / Tandem Repeat Sequences / Cytarabine / Benzothiazoles / Fms-Like Tyrosine Kinase 3 Type of study: Diagnostic_studies / Prognostic_studies Limits: Aged / Animals / Humans / Male Language: En Journal: Exp Hematol Year: 2017 Document type: Article Affiliation country: Estados Unidos Country of publication: Países Bajos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylurea Compounds / Leukemia, Myeloid, Acute / Gene Duplication / Tandem Repeat Sequences / Cytarabine / Benzothiazoles / Fms-Like Tyrosine Kinase 3 Type of study: Diagnostic_studies / Prognostic_studies Limits: Aged / Animals / Humans / Male Language: En Journal: Exp Hematol Year: 2017 Document type: Article Affiliation country: Estados Unidos Country of publication: Países Bajos