Tyrosyl-DNA phosphodiesterase inhibitors: Progress and potential.

Laev, Sergey S; Salakhutdinov, Nariman F; Lavrik, Olga I

Laev, Sergey S; Salakhutdinov, Nariman F; Lavrik, Olga I.

Affiliation

Laev SS; Vorozhtsov Institute of Organic Chemistry, Siberian Division, Russian Academy of Sciences, pr. akademika Lavrent'eva 9, Novosibirsk 630090, Russian Federation. Electronic address: sergey@nioch.nsc.ru.
Salakhutdinov NF; Vorozhtsov Institute of Organic Chemistry, Siberian Division, Russian Academy of Sciences, pr. akademika Lavrent'eva 9, Novosibirsk 630090, Russian Federation; Novosibirsk State University, Pirogova Str. 2, Novosibirsk 630090, Russian Federation.
Lavrik OI; Novosibirsk State University, Pirogova Str. 2, Novosibirsk 630090, Russian Federation; Novosibirsk Institute of Chemical Biology and Fundamental Medicine, Siberian Division, Russian Academy of Sciences, pr. akademika Lavrent'eva 8, Novosibirsk 630090, Russian Federation.

Bioorg Med Chem ; 24(21): 5017-5027, 2016 11 01.

Article in En | MEDLINE | ID: mdl-27687971

Subject(s)
Key words

Camptothecin; DNA repair; Indenoisoquinolines; Tdp1; Tdp1 inhibitors; Tdp2; Tdp2 inhibitors; Top1 inhibitors; Top2 inhibitors; Topoisomerase; Tyrosyl-DNA phosphodiesterase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphodiesterase Inhibitors / DNA Topoisomerases, Type II / DNA Topoisomerases, Type I / DNA-Binding Proteins / Antigens, Neoplasm Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Document type: Article Country of publication: Reino Unido

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