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BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models.
Politz, Oliver; Siegel, Franziska; Bärfacker, Lars; Bömer, Ulf; Hägebarth, Andrea; Scott, William J; Michels, Martin; Ince, Stuart; Neuhaus, Roland; Meyer, Kirstin; Fernández-Montalván, Amaury Ernesto; Liu, Ningshu; von Nussbaum, Franz; Mumberg, Dominik; Ziegelbauer, Karl.
Affiliation
  • Politz O; Bayer AG, Global Drug Discovery, 13342 Berlin, Germany.
  • Siegel F; Bayer AG, Global Drug Discovery, 13342 Berlin, Germany.
  • Bärfacker L; Bayer AG, Global Drug Discovery, 42096 Wuppertal, Germany.
  • Bömer U; Bayer AG, Global Drug Discovery, 13342 Berlin, Germany.
  • Hägebarth A; Bayer AG, Global Drug Discovery, 13342 Berlin, Germany.
  • Scott WJ; Bayer HealthCare Pharmaceuticals Inc, Whippany, NJ 07981-0915.
  • Michels M; Bayer AG, Global Drug Discovery, 42096 Wuppertal, Germany.
  • Ince S; Bayer HealthCare Pharmaceuticals Inc, Whippany, NJ 07981-0915.
  • Neuhaus R; Bayer AG, Global Drug Discovery, 13342 Berlin, Germany.
  • Meyer K; Bayer AG, Global Drug Discovery, 13342 Berlin, Germany.
  • Fernández-Montalván AE; Bayer AG, Global Drug Discovery, 13342 Berlin, Germany.
  • Liu N; Bayer AG, Global Drug Discovery, 13342 Berlin, Germany.
  • von Nussbaum F; Bayer S.A.S./Bayer CropScience, Small Molecules Research, Disease Control Chemistry, 69263 Lyon, France.
  • Mumberg D; Bayer AG, Global Drug Discovery, 13342 Berlin, Germany.
  • Ziegelbauer K; Bayer AG, Global Drug Discovery, 13342 Berlin, Germany.
Int J Cancer ; 140(2): 449-459, 2017 Jan 15.
Article in En | MEDLINE | ID: mdl-27699769
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfones / Signal Transduction / Protein Kinase Inhibitors / Proto-Oncogene Proteins c-akt / Nitriles Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Int J Cancer Year: 2017 Document type: Article Affiliation country: Alemania
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfones / Signal Transduction / Protein Kinase Inhibitors / Proto-Oncogene Proteins c-akt / Nitriles Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Int J Cancer Year: 2017 Document type: Article Affiliation country: Alemania