Impact of glucose tolerance status on the development of coronary artery disease among working-age men.
Diabetes Metab
; 43(3): 261-264, 2017 Jun.
Article
in En
| MEDLINE
| ID: mdl-27712966
ABSTRACT
AIMS:
To examine the impact of glucose tolerance status on the development of coronary artery disease (CAD) in working-age men in Japan.METHODS:
This population-based retrospective cohort study included 111,621 men aged 31-60 years [63,558 with normal glucose tolerance (NGT); 37,126 with prediabetes; 10,937 with diabetes]. The Cox proportional-hazards regression model was used to identify variables related to the incidence of CAD.RESULTS:
Multivariate analysis showed that, compared with NGT, diabetes increased the risk of CAD by 17.3 times (95% CI 6.36-47.0) at ages 31-40 years, by 2.74 times (95% CI 1.85-4.05) at ages 41-50 years and by 2.47 times (95% CI 1.69-3.59) at ages 51-60 years. The HRs for CAD in men with diabetes aged 31-40 equaled that of men with NGT aged 51-60 [18.2 (7.15-46.4) and 19.4 (8.28-45.4), respectively].CONCLUSION:
The impact of diabetes on CAD was markedly greater in men aged 31-40 years compared with those aged 41-60 years.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Coronary Artery Disease
/
Glucose Intolerance
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Diabetes Metab
Journal subject:
ENDOCRINOLOGIA
/
METABOLISMO
Year:
2017
Document type:
Article
Affiliation country:
Japón