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An in silico analysis of oxygen uptake of a mild COPD patient during rest and exercise using a portable oxygen concentrator.
Katz, Ira; Pichelin, Marine; Montesantos, Spyridon; Kang, Min-Yeong; Sapoval, Bernard; Zhu, Kaixian; Thevenin, Charles-Philippe; McCoy, Robert; Martin, Andrew R; Caillibotte, Georges.
Affiliation
  • Katz I; Medical R&D, Air Liquide Santé International, Centre de Recherche Paris-Saclay, Les Loges-en-Josas, France; Department of Mechanical Engineering, Lafayette College, Easton, PA, USA.
  • Pichelin M; Medical R&D, Air Liquide Santé International, Centre de Recherche Paris-Saclay, Les Loges-en-Josas, France.
  • Montesantos S; Medical R&D, Air Liquide Santé International, Centre de Recherche Paris-Saclay, Les Loges-en-Josas, France.
  • Kang MY; Physique de la Matière Condensée, CNRS, Ecole Polytechnique, Palaiseau.
  • Sapoval B; Physique de la Matière Condensée, CNRS, Ecole Polytechnique, Palaiseau; Centre de Mathématiques et de leurs Applications, CNRS, UniverSud, Cachan.
  • Zhu K; Centre Explor!, Air Liquide Healthcare, Gentilly, France.
  • Thevenin CP; Centre Explor!, Air Liquide Healthcare, Gentilly, France.
  • McCoy R; Valley Inspired Products, Inc, Apple Valley, MN, USA.
  • Martin AR; Department of Mechanical Engineering, University of Alberta, Edmonton, AB, Canada.
  • Caillibotte G; Medical R&D, Air Liquide Santé International, Centre de Recherche Paris-Saclay, Les Loges-en-Josas, France.
Int J Chron Obstruct Pulmon Dis ; 11: 2427-2434, 2016.
Article in En | MEDLINE | ID: mdl-27729783
Oxygen treatment based on intermittent-flow devices with pulse delivery modes available from portable oxygen concentrators (POCs) depends on the characteristics of the delivered pulse such as volume, pulse width (the time of the pulse to be delivered), and pulse delay (the time for the pulse to be initiated from the start of inhalation) as well as a patient's breathing characteristics, disease state, and respiratory morphology. This article presents a physiological-based analysis of the performance, in terms of blood oxygenation, of a commercial POC at different settings using an in silico model of a COPD patient at rest and during exercise. The analysis encompasses experimental measurements of pulse volume, width, and time delay of the POC at three different settings and two breathing rates related to rest and exercise. These experimental data of device performance are inputs to a physiological-based model of oxygen uptake that takes into account the real dynamic nature of gas exchange to illustrate how device- and patient-specific factors can affect patient oxygenation. This type of physiological analysis that considers the true effectiveness of oxygen transfer to the blood, as opposed to delivery to the nose (or mouth), can be instructive in applying therapies and designing new devices.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxygen / Oxygen Inhalation Therapy / Rest / Computer Simulation / Exercise / Pulmonary Disease, Chronic Obstructive / Lung Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Int J Chron Obstruct Pulmon Dis Year: 2016 Document type: Article Affiliation country: Estados Unidos Country of publication: Nueva Zelanda

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxygen / Oxygen Inhalation Therapy / Rest / Computer Simulation / Exercise / Pulmonary Disease, Chronic Obstructive / Lung Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Int J Chron Obstruct Pulmon Dis Year: 2016 Document type: Article Affiliation country: Estados Unidos Country of publication: Nueva Zelanda