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Candida albicans glutathione reductase downregulates Efg1-mediated cyclic AMP/protein kinase A pathway and leads to defective hyphal growth and virulence upon decreased cellular methylglyoxal content accompanied by activating alcohol dehydrogenase and glycolytic enzymes.
Ku, MyungHee; Baek, Yong-Un; Kwak, Min-Kyu; Kang, Sa-Ouk.
Affiliation
  • Ku M; Laboratory of Biophysics, School of Biological Sciences, and Institute of Microbiology, Seoul National University, Seoul 151-742, Republic of Korea.
  • Baek YU; Laboratory of Biophysics, School of Biological Sciences, and Institute of Microbiology, Seoul National University, Seoul 151-742, Republic of Korea.
  • Kwak MK; Laboratory of Biophysics, School of Biological Sciences, and Institute of Microbiology, Seoul National University, Seoul 151-742, Republic of Korea. Electronic address: genie6@snu.ac.kr.
  • Kang SO; Laboratory of Biophysics, School of Biological Sciences, and Institute of Microbiology, Seoul National University, Seoul 151-742, Republic of Korea. Electronic address: kangsaou@snu.ac.kr.
Biochim Biophys Acta Gen Subj ; 1861(4): 772-788, 2017 Apr.
Article in En | MEDLINE | ID: mdl-27751952
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyruvaldehyde / Transcription Factors / Alcohol Dehydrogenase / Candida albicans / Fungal Proteins / Cyclic AMP-Dependent Protein Kinases / Cyclic AMP / DNA-Binding Proteins / Glutathione Reductase Type of study: Prognostic_studies Language: En Journal: Biochim Biophys Acta Gen Subj Year: 2017 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyruvaldehyde / Transcription Factors / Alcohol Dehydrogenase / Candida albicans / Fungal Proteins / Cyclic AMP-Dependent Protein Kinases / Cyclic AMP / DNA-Binding Proteins / Glutathione Reductase Type of study: Prognostic_studies Language: En Journal: Biochim Biophys Acta Gen Subj Year: 2017 Document type: Article