Ethenesulfonyl Fluoride (ESF): An On-Water Procedure for the Kilogram-Scale Preparation.
J Org Chem
; 81(22): 11360-11362, 2016 11 18.
Article
in En
| MEDLINE
| ID: mdl-27764941
ABSTRACT
A two-step, on-water procedure for the synthesis of ethenesulfonyl fluoride (ESF) is described. 2-Chloroethanesulfonyl fluoride is made via a neat reaction with an aqueous, nearly saturated potassium bifluoride solution from readily available 2-chloroethanesulfonyl chloride. The subsequent dehydrochlorination of 2-chloroethanesulfonyl fluoride proceeds neatly with magnesium oxide as the base in an aqueous suspension to give ESF. This recipe allows the preparation of ESF in 98% yield on a kilogram scale.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sulfhydryl Compounds
/
Water
Language:
En
Journal:
J Org Chem
Year:
2016
Document type:
Article
Affiliation country:
Estados Unidos