tcpl: the ToxCast pipeline for high-throughput screening data.
Bioinformatics
; 33(4): 618-620, 2017 02 15.
Article
in En
| MEDLINE
| ID: mdl-27797781
Motivation: Large high-throughput screening (HTS) efforts are widely used in drug development and chemical toxicity screening. Wide use and integration of these data can benefit from an efficient, transparent and reproducible data pipeline. Summary: The tcpl R package and its associated MySQL database provide a generalized platform for efficiently storing, normalizing and dose-response modeling of large high-throughput and high-content chemical screening data. The novel dose-response modeling algorithm has been tested against millions of diverse dose-response series, and robustly fits data with outliers and cytotoxicity-related signal loss. Availability and Implementation: tcpl is freely available on the Comprehensive R Archive Network under the GPL-2 license. Contact: martin.matt@epa.gov.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Software
/
Toxicity Tests
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Drug Evaluation, Preclinical
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High-Throughput Screening Assays
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Models, Biological
Type of study:
Diagnostic_studies
/
Screening_studies
Language:
En
Journal:
Bioinformatics
Journal subject:
INFORMATICA MEDICA
Year:
2017
Document type:
Article
Country of publication:
Reino Unido