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A Micropatterned Human Pluripotent Stem Cell-Based Ventricular Cardiac Anisotropic Sheet for Visualizing Drug-Induced Arrhythmogenicity.
Shum, Angie M Y; Che, Hui; Wong, Andy On-Tik; Zhang, Chenzi; Wu, Hongkai; Chan, Camie W Y; Costa, Kevin; Khine, Michelle; Kong, Chi-Wing; Li, Ronald A.
Affiliation
  • Shum AM; Stem Cell & Regenerative Medicine Consortium, LKS Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong.
  • Che H; Stem Cell & Regenerative Medicine Consortium, LKS Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong.
  • Wong AO; Stem Cell & Regenerative Medicine Consortium, LKS Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong.
  • Zhang C; Stem Cell & Regenerative Medicine Consortium, LKS Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong.
  • Wu H; Biomedical Engineering, Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong.
  • Chan CW; Novoheart Ltd., Hong Kong Science Park, Shatin, Hong Kong.
  • Costa K; Icahn School of Medicine at Mount Sinai, Manhattan, NYC, 10029-5674, USA.
  • Khine M; Biomedical Engineering, University of California at Irvine, Irvine, CA, 92697-2715, USA.
  • Kong CW; Stem Cell & Regenerative Medicine Consortium, LKS Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong.
  • Li RA; Dr. Li Dak-Sum Research Centre, University of Hong Kong, Pokfulam, Hong Kong.
Adv Mater ; 29(1)2017 Jan.
Article in En | MEDLINE | ID: mdl-27805726
ABSTRACT
A novel cardiomimetic biohybrid material, termed as the human ventricular cardiac anisotropic sheet (hvCAS) is reported. Well-characterized human pluripotent stem-cell-derived ventricular cardiomyocytes are strategically aligned to reproduce key electrophysiological features of native human ventricle, which, along with specific selection criteria, allows for a direct visualization of arrhythmic spiral re-entry and represents a revolutionary tool to assess preclinical drug-induced arrhythmogenicity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pluripotent Stem Cells Limits: Humans Language: En Journal: Adv Mater Journal subject: BIOFISICA / QUIMICA Year: 2017 Document type: Article Affiliation country: Hong Kong
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pluripotent Stem Cells Limits: Humans Language: En Journal: Adv Mater Journal subject: BIOFISICA / QUIMICA Year: 2017 Document type: Article Affiliation country: Hong Kong