Your browser doesn't support javascript.
loading
Exosomes in Tumor Angiogenesis.
Salem, Karma Z; Moschetta, Michele; Sacco, Antonio; Imberti, Luisa; Rossi, Giuseppe; Ghobrial, Irene M; Manier, Salomon; Roccaro, Aldo M.
Affiliation
  • Salem KZ; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Moschetta M; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Sacco A; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Imberti L; ASST Spedali Civili, Department of Medical Oncology, CREA Laboratory, Brescia, Italy.
  • Rossi G; ASST Spedali Civili, Department of Medical Oncology, CREA Laboratory, Brescia, Italy.
  • Ghobrial IM; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Manier S; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Roccaro AM; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. aldo_roccaro@dfci.harvard.edu.
Methods Mol Biol ; 1464: 25-34, 2016.
Article in En | MEDLINE | ID: mdl-27858353
ABSTRACT
Exosomes are small vesicles ranging in size between 30 and 150 nm, derived from the luminal membranes of the endosome and are constitutively released by fusion with the cell membrane. Several studies have revealed that exosomes play crucial roles in mediating local and systemic cell communication through the horizontal transfer of information in the form of nucleic material and proteins. This is particularly relevant in the context of the tumor-microenvironment cross talk. Here we describe the method of isolating exosomes and their role in modifying the tumor environment and more specifically in enabling metastasis and promoting angiogenesis.
Subject(s)
Key words
Search on Google
Add to My VHL
Print
XML
PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Exosomes / Neoplasms / Neovascularization, Pathologic Limits: Humans Language: En Journal: Methods Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2016 Document type: Article Affiliation country: Estados Unidos
Search on Google
Add to My VHL
Print
XML
PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Exosomes / Neoplasms / Neovascularization, Pathologic Limits: Humans Language: En Journal: Methods Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2016 Document type: Article Affiliation country: Estados Unidos