Polymorphic ochratoxin A hydroxylation in rat strains phenotyped as poor and extensive metabolizers of debrisoquine.
Xenobiotica
; 19(2): 225-30, 1989 Feb.
Article
in En
| MEDLINE
| ID: mdl-2786290
ABSTRACT
1. Dark agouti (DA) and Lewis rat strains, which show a genetic polymorphism for debrisoquine-4-hydroxylation, were treated either with a single dose of ochratoxin A (OA) or for 8 weeks with 5 doses per week. Levels of OA and its 4-hydroxy metabolite (4-hydroxy-OA) excreted in urine were determined. 2. At all doses, the metabolic ratio of OA4-hydroxy-OA was two to five times greater in DA than in Lewis rats, as was the metabolic ratio of debrisoquine4-hydroxy-debrisoquine. These results are consistent with our previous findings in vitro that hepatic and renal OA 4-hydroxylase activity is three to four times lower in DA than in Lewis rats. These data give further support to the possible co-segregation of genes regulating OA and debrisoquine 4-hydroxylation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rats, Inbred Lew
/
Rats, Inbred Strains
/
Debrisoquin
/
Isoquinolines
/
Ochratoxins
Limits:
Animals
Language:
En
Journal:
Xenobiotica
Year:
1989
Document type:
Article
Affiliation country:
Francia