Tetrahydroquinoline-based tricyclic amines as potent and selective agonists of the 5-HT2C receptor.
Bioorg Med Chem Lett
; 26(24): 5877-5882, 2016 12 15.
Article
in En
| MEDLINE
| ID: mdl-27864071
ABSTRACT
The syntheses, structure-activity relationships (SARs), and biological activities of tetrahydroquinoline-based tricyclic amines as 5-HT2C receptor agonists are reported. An early lead containing a highly unique 6,6,7-ring system was optimized for both in vitro potency and selectivity at the related 5-HT2B receptor. Orally bioactive, potent, and selective 6,6,6-tricyclic 5-HT2C agonists were identified.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quinolines
/
Receptor, Serotonin, 5-HT2C
/
Serotonin 5-HT2 Receptor Agonists
/
Amines
Limits:
Animals
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2016
Document type:
Article