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Flexible synthesis of cationic peptide-porphyrin derivatives for light-triggered drug delivery and photodynamic therapy.
Dondi, R; Yaghini, E; Tewari, K M; Wang, L; Giuntini, F; Loizidou, M; MacRobert, A J; Eggleston, I M.
Affiliation
  • Dondi R; Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK. ie203@bath.ac.uk.
  • Yaghini E; UCL Division of Surgery and Interventional Science, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK.
  • Tewari KM; Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK. ie203@bath.ac.uk.
  • Wang L; Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK. ie203@bath.ac.uk and School of Pharmaceutical Sciences, Shandong University, Jinan, China.
  • Giuntini F; Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK. ie203@bath.ac.uk.
  • Loizidou M; UCL Division of Surgery and Interventional Science, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK.
  • MacRobert AJ; UCL Division of Surgery and Interventional Science, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK.
  • Eggleston IM; Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK. ie203@bath.ac.uk.
Org Biomol Chem ; 14(48): 11488-11501, 2016 Dec 07.
Article in En | MEDLINE | ID: mdl-27886311
ABSTRACT
Efficient syntheses of cell-penetrating peptide-porphyrin conjugates are described using a variety of bioconjugation chemistries. This provides a flexible means to convert essentially hydrophobic tetrapyrolle photosensitisers into amphiphilic derivatives which are well-suited for use in light-triggered drug delivery by photochemical internalisation (PCI) and targeted photodynamic therapy (PDT).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenothiazines / Photochemotherapy / Porphyrins / Drug Delivery Systems / Antimicrobial Cationic Peptides / Light Language: En Journal: Org Biomol Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Document type: Article Affiliation country: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenothiazines / Photochemotherapy / Porphyrins / Drug Delivery Systems / Antimicrobial Cationic Peptides / Light Language: En Journal: Org Biomol Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Document type: Article Affiliation country: Reino Unido