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Kinase Inhibition Leads to Hormesis in a Dual Phosphorylation-Dephosphorylation Cycle.
Rashkov, Peter; Barrett, Ian P; Beardmore, Robert E; Bendtsen, Claus; Gudelj, Ivana.
Affiliation
  • Rashkov P; School of Biosciences, University of Exeter, Exeter, United Kingdom.
  • Barrett IP; Discovery Sciences, Innovative Medicines and Early Development, AstraZeneca, Cambridge, United Kingdom.
  • Beardmore RE; School of Biosciences, University of Exeter, Exeter, United Kingdom.
  • Bendtsen C; Discovery Sciences, Innovative Medicines and Early Development, AstraZeneca, Cambridge, United Kingdom.
  • Gudelj I; School of Biosciences, University of Exeter, Exeter, United Kingdom.
PLoS Comput Biol ; 12(11): e1005216, 2016 Nov.
Article in En | MEDLINE | ID: mdl-27898662
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphorylation / Protein Kinases / Cell Physiological Phenomena / Protein Kinase Inhibitors / Hormesis / Models, Biological Limits: Animals / Humans Language: En Journal: PLoS Comput Biol Journal subject: BIOLOGIA / INFORMATICA MEDICA Year: 2016 Document type: Article Affiliation country: Reino Unido Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphorylation / Protein Kinases / Cell Physiological Phenomena / Protein Kinase Inhibitors / Hormesis / Models, Biological Limits: Animals / Humans Language: En Journal: PLoS Comput Biol Journal subject: BIOLOGIA / INFORMATICA MEDICA Year: 2016 Document type: Article Affiliation country: Reino Unido Country of publication: Estados Unidos