The correlation between children's status asthmatics and interstitial lung disease.

ABSTRACT

OBJECTIVE: Investigating the correlation between children's status asthmatics and interstitial lung disease (ILD). PATIENTS AND METHODS: We continuously selected 20 cases of children's status asthmatics combined with ILD (group A), 20 cases of pure status asthmatics (group B), 20 cases of pure ILD (group C) and 20 cases of healthy children (group D). We measured Th1/Th2 by flow cytometry as well as the level of expression of hs-CRP, IL-7 cytokines (TSLP), monocyte chemoattractant protein-1 (MCP-1) and anti-Jo-1 antibody by ELISA method. RESULTS: Th1 and Th1/Th2 of groups A and B were significantly lower than those of group C and D. Th2 was significantly (p<0.05) higher than that of groups C and D. The level of expression of hs-CRP, TSLP, MCP-1 and anti-Jo-1 antibody in the groups A and B were all significantly higher (p<0.05) than those of groups C and D. There were differences of the above index of the comparison between groups A and B, but no difference between groups C and D. CONCLUSIONS: Children's status asthmatics and ILD may correlate with the abnormal expression of Th1/Th2, hs-CRP, TSLP, MCP-1 and anti-Jo-1 antibody.