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Cyclic Vomiting Syndrome is characterized by altered functional brain connectivity of the insular cortex: A cross-comparison with migraine and healthy adults.
Ellingsen, D-M; Garcia, R G; Lee, J; Lin, R L; Kim, J; Thurler, A H; Castel, S; Dimisko, L; Rosen, B R; Hadjikhani, N; Kuo, B; Napadow, V.
Affiliation
  • Ellingsen DM; Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Garcia RG; Department of Psychology, University of Oslo, Oslo, Norway.
  • Lee J; Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Lin RL; Neuroscience Group, School of Medicine, Universidad de Santander (UDES), Bucaramanga, Colombia.
  • Kim J; Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Thurler AH; Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Castel S; Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Dimisko L; Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Rosen BR; Korean Institute for Oriental Medicine, Daejeon, Korea.
  • Hadjikhani N; Department of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Kuo B; Department of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Napadow V; Department of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Neurogastroenterol Motil ; 29(6)2017 Jun.
Article in En | MEDLINE | ID: mdl-27910222
ABSTRACT
Cyclic Vomiting Syndrome (CVS) has been linked to episodic migraine, yet little is known about the precise brain-based mechanisms underpinning CVS, and whether these associated conditions share similar pathophysiology. We investigated the functional integrity of salience (SLN) and sensorimotor (SMN) intrinsic connectivity networks in CVS, migraine and healthy controls using brain functional Magnetic Resonance Imaging. CVS, relative to both migraine and controls, showed increased SLN connectivity to middle/posterior insula, a key brain region for nausea and viscerosensory processing. In contrast, this same region showed diminished SMN connectivity in both CVS and migraine. These results highlight both unique and potentially shared pathophysiology between these conditions, and suggest a potential target for therapeutics in future studies.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vomiting / Brain / Cerebral Cortex / Migraine Disorders Limits: Adult / Female / Humans / Male Language: En Journal: Neurogastroenterol Motil Journal subject: GASTROENTEROLOGIA / NEUROLOGIA Year: 2017 Document type: Article Affiliation country: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vomiting / Brain / Cerebral Cortex / Migraine Disorders Limits: Adult / Female / Humans / Male Language: En Journal: Neurogastroenterol Motil Journal subject: GASTROENTEROLOGIA / NEUROLOGIA Year: 2017 Document type: Article Affiliation country: Estados Unidos