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CCT complex restricts neuropathogenic protein aggregation via autophagy.
Pavel, Mariana; Imarisio, Sara; Menzies, Fiona M; Jimenez-Sanchez, Maria; Siddiqi, Farah H; Wu, Xiaoting; Renna, Maurizio; O'Kane, Cahir J; Crowther, Damian C; Rubinsztein, David C.
Affiliation
  • Pavel M; Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK.
  • Imarisio S; Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK.
  • Menzies FM; Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK.
  • Jimenez-Sanchez M; Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK.
  • Siddiqi FH; Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK.
  • Wu X; Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK.
  • Renna M; Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK.
  • O'Kane CJ; Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK.
  • Crowther DC; Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK.
  • Rubinsztein DC; MedImmune Limited, Aaron Klug Building, Granta Park, Cambridge CB21 6GH, UK.
Nat Commun ; 7: 13821, 2016 12 08.
Article in En | MEDLINE | ID: mdl-27929117
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Chaperonin Containing TCP-1 / Protein Aggregation, Pathological / Autophagosomes / Huntingtin Protein Limits: Animals / Female / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2016 Document type: Article Affiliation country: Reino Unido Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Chaperonin Containing TCP-1 / Protein Aggregation, Pathological / Autophagosomes / Huntingtin Protein Limits: Animals / Female / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2016 Document type: Article Affiliation country: Reino Unido Country of publication: Reino Unido