[Progress in research on genetic polymorphisms and sequence-based typing of KIR genes].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
; 33(6): 867-870, 2016 Dec 10.
Article
in Zh
| MEDLINE
| ID: mdl-27984624
ABSTRACT
Killer cell immunoglobulin-like receptors (KIRs) are members of the immunoglobulin superfamily expressed on natural killer (NK) cells and a subset of T cells. Given the receptor-ligand relationship between certain KIR and human leukocyte antigen (HLA) classâ
molecules, the KIRs are involved in the regulation of NK cell activation through conveying activating or inhibitory signals, which plays an important role in immunities involved in transplantation, tumor, infection as well as autoimmune diseases. This paper has provided a review for the research on KIR gene polymorphisms and summarized the characteristics of the sequence-based typing method for KIR genes.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polymorphism, Genetic
/
Histocompatibility Antigens Class I
/
Receptors, KIR
Limits:
Humans
Language:
Zh
Journal:
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
Journal subject:
GENETICA MEDICA
Year:
2016
Document type:
Article
Affiliation country:
China