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[EVI1 expression, clinical and cytogenetical characteristics in 447 patients with acute myeloid leukemia].
He, X F; Wang, Q R; Cen, J N; Qiu, H Y; Sun, A N; Chen, S N; Wu, D P.
Affiliation
  • He XF; Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Collaborative Innovation Center of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou 215006, China.
Zhonghua Xue Ye Xue Za Zhi ; 37(11): 936-941, 2016 Nov 14.
Article in Zh | MEDLINE | ID: mdl-27995876
ABSTRACT

Objective:

To investigate EVI1 expression and its associated clinical and cytogenetic characteristics in 447 acute myeloid leukemia (AML) patients.

Methods:

EVI1 expressions were measured in 447 AML cases from Jan. 2007 to Apr. 2015 to couple with clinical, cytogenetic and mutations' characteristics to summarize the features of AMLs with high EVI1 expression.

Results:

17.9% of AML were high EVI1 expression (EVI1 +), and the remainder low EVI1 expression (EVI1-). No significant differences between the two groups in terms of age, sex, hemoglobin level, white blood cell count and platelet count were observed. More M0, M5 and M6 subtypes were observed in EVI1+ group (P= 0.027, 0.004 and 0.011, respectively). Cytogenetic abnormalities of 11q15, 11q23/MLL, 3q26, -7/7q- and t (9;11) were observed more frequently in EVI1 + group (P<0.001, <0.001, <0.001, <0.001, =0.014, respectively). Normal karyotype, inv (16), t (8;21) were observed more frequent in EVI1- group (P=0.001, 0.009, 0.002, respectively). EVI1 + was more observed in high risk cytogenetics. Mutation of NPM1 was more observed in EVI1- group (P <0.001). Remission rate in EVI1 + group was significantly lower than EVI1- group (P<0.001). Leukemia-free survival was improved in EVI1 + AML patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT).

Conclusions:

High EVI1 expression was more observed in FAB subgroup M5, harbored more cytogenetic abnormalities of 11p15, 11q23/MLL, 3q26 rearrangement, -7/7q- and t (9;11). Remission rate of high EVI1 expression AML was lower, which could be improved by allo-HSCT.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogenes / Leukemia, Myeloid, Acute / Chromosome Aberrations / DNA-Binding Proteins / MDS1 and EVI1 Complex Locus Protein Type of study: Prognostic_studies Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Language: Zh Journal: Zhonghua Xue Ye Xue Za Zhi Year: 2016 Document type: Article Affiliation country: China

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogenes / Leukemia, Myeloid, Acute / Chromosome Aberrations / DNA-Binding Proteins / MDS1 and EVI1 Complex Locus Protein Type of study: Prognostic_studies Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Language: Zh Journal: Zhonghua Xue Ye Xue Za Zhi Year: 2016 Document type: Article Affiliation country: China