The small GTPase ARF6 regulates protein trafficking to control cellular function during development and in disease.
Small GTPases
; 10(1): 1-12, 2019 01.
Article
in En
| MEDLINE
| ID: mdl-28001501
ABSTRACT
The activation of the small GTPase ARF6 has been implicated in promoting several pathological processes related to vascular instability and tumor formation, growth, and metastasis. ARF6 also plays a vital role during embryonic development. Recent studies have suggested that ARF6 carries out these disparate functions primarily by controlling protein trafficking within the cell. ARF6 helps direct proteins to intracellular or extracellular locations where they function in normal cellular responses during development and in pathological processes later in life. This transport of proteins is accomplished through a variety of mechanisms, including endocytosis and recycling, microvesicle release, and as yet uncharacterized processes. This Commentary will explore the functions of ARF6, while focusing on the role of this small GTPase in development and postnatal physiology, regulating barrier function and diseases associated with its loss, and tumor formation, growth, and metastasis.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
ADP-Ribosylation Factors
Limits:
Animals
/
Humans
Language:
En
Journal:
Small GTPases
Year:
2019
Document type:
Article
Affiliation country:
Estados Unidos