Mammalian Polycistronic mRNAs and Disease.
Trends Genet
; 33(2): 129-142, 2017 02.
Article
in En
| MEDLINE
| ID: mdl-28012572
ABSTRACT
Our understanding of gene expression has come far since the 'one-gene one-polypeptide' hypothesis proposed by Beadle and Tatum. In this review, we address the gradual recognition that a growing number of polycistronic genes, originally discovered in viruses, are being identified within the mammalian genome, and that these may provide new insights into disease mechanisms and treatment. We carried out a systematic literature review identifying 13 mammalian genes for which there is evidence for polycistronic expression via translation through an internal ribosome entry site (IRES). Although the canonical mechanism of translation initiation has been studied extensively, here we highlight a process of noncanonical translation, IRES-mediated translation, that is a growing source for understanding complex inheritance, the elucidation of disease mechanisms, and the discovery of novel therapeutic targets. Identification of additional polycistronic genes may provide new insights into disease therapy and allow for new discoveries of both translational and disease mechanisms.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Protein Biosynthesis
/
RNA, Messenger
/
Internal Ribosome Entry Sites
/
Genetic Diseases, Inborn
Type of study:
Systematic_reviews
Limits:
Animals
/
Humans
Language:
En
Journal:
Trends Genet
Journal subject:
GENETICA
Year:
2017
Document type:
Article
Affiliation country:
Estados Unidos