Aromatase changes in depression: A postmortem and animal experimental study.
Psychoneuroendocrinology
; 77: 56-62, 2017 03.
Article
in En
| MEDLINE
| ID: mdl-28024269
ABSTRACT
A hyperactive hypothalamo-pituitary-adrenal (HPA) axis is a prominent feature in depression. It has been shown that androgens inhibit HPA activity and that estrogens stimulate it. We have therefore investigated, in human postmortem hypothalamus, whether depression features an increase in aromatase, which is the rate-limiting enzyme for the conversion of androgens to estrogens. In addition, we have tested the effect of an aromatase inhibitor on depression-like symptoms in a frequently used animal model for depression. At first, aromatase immunoreactivity (ir) was quantified in the central part of the hypothalamic paraventricular nucleus (PVN) of 10 major depressive disorder (MDD) patients and 10 well-matched control subjects. Subsequently an animal experimental study was performed using the chronic unpredictable mild stress (CUMS) rats as depression model. The effect of administration of 1,4,6-androstatriene-3,17-dione (ATD), an aromatase inhibitor, was investigated by silastic capsule implantation. In the postmortem study, the amount of PVN aromatase-ir decreased significantly in the MDD group compared to the controls (P=0.029). In the animal study, ATD was found to cause significantly increased testosterone (T) levels, both in plasma and in the hypothalamus. However, ATD administration did not show significant effects on the depression-like behaviors or plasma corticosterone levels in CUMS rats. Based on our observations in human postmortem material and the animal experiment, we have to conclude that alterations in aromatase in adulthood do not seem to play a major role in the pathogenesis of the symptoms of depression.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Paraventricular Hypothalamic Nucleus
/
Aromatase
/
Depressive Disorder, Major
Type of study:
Prognostic_studies
Limits:
Aged
/
Aged80
/
Animals
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Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Psychoneuroendocrinology
Year:
2017
Document type:
Article
Affiliation country:
China