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Iterative Focused Screening with Biological Fingerprints Identifies Selective Asc-1 Inhibitors Distinct from Traditional High Throughput Screening.
Kutchukian, Peter S; Warren, Lee; Magliaro, Brian C; Amoss, Adam; Cassaday, Jason A; O'Donnell, Gregory; Squadroni, Brian; Zuck, Paul; Pascarella, Danette; Culberson, J Chris; Cooke, Andrew J; Hurzy, Danielle; Schlegel, Kelly-Ann Sondra; Thomson, Fiona; Johnson, Eric N; Uebele, Victor N; Hermes, Jeffrey D; Parmentier-Batteur, Sophie; Finley, Michael.
Affiliation
  • Kutchukian PS; Modeling and Informatics, Merck & Co., Inc., MRL , Boston, Massachusetts, United States.
  • Warren L; Neuroscience, Merck & Co., Inc., MRL , West Point, Pennsylvania, United States.
  • Magliaro BC; Pharmacology, Merck & Co., Inc., MRL , West Point, Pennsylvania, United States.
  • Amoss A; Screening and Protein Sciences, Merck & Co., Inc., MRL , North Wales, Pennsylvania, United States.
  • Cassaday JA; Screening and Protein Sciences, Merck & Co., Inc., MRL , North Wales, Pennsylvania, United States.
  • O'Donnell G; Screening and Protein Sciences, Merck & Co., Inc., MRL , North Wales, Pennsylvania, United States.
  • Squadroni B; Screening and Protein Sciences, Merck & Co., Inc., MRL , North Wales, Pennsylvania, United States.
  • Zuck P; Screening and Protein Sciences, Merck & Co., Inc., MRL , North Wales, Pennsylvania, United States.
  • Pascarella D; Pharmacology, Merck & Co., Inc., MRL , West Point, Pennsylvania, United States.
  • Culberson JC; Modeling and Informatics, Merck & Co., Inc., MRL , West Point, Pennsylvania, United States.
  • Cooke AJ; Chemistry, Merck & Co., Inc., MRL , West Point, Pennsylvania, United States.
  • Hurzy D; Chemistry, Merck & Co., Inc., MRL , West Point, Pennsylvania, United States.
  • Schlegel KS; Chemistry, Merck & Co., Inc., MRL , West Point, Pennsylvania, United States.
  • Thomson F; Neuroscience, Merck & Co., Inc., MRL , West Point, Pennsylvania, United States.
  • Johnson EN; Screening and Protein Sciences, Merck & Co., Inc., MRL , North Wales, Pennsylvania, United States.
  • Uebele VN; Screening and Protein Sciences, Merck & Co., Inc., MRL , North Wales, Pennsylvania, United States.
  • Hermes JD; Screening and Protein Sciences, Merck & Co., Inc., MRL , North Wales, Pennsylvania, United States.
  • Parmentier-Batteur S; Neuroscience, Merck & Co., Inc., MRL , West Point, Pennsylvania, United States.
  • Finley M; Screening and Protein Sciences, Merck & Co., Inc., MRL , North Wales, Pennsylvania, United States.
ACS Chem Biol ; 12(2): 519-527, 2017 02 17.
Article in En | MEDLINE | ID: mdl-28032990
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Amino Acid Transport System y/ / High-Throughput Screening Assays Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Animals / Humans Language: En Journal: ACS Chem Biol Year: 2017 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Amino Acid Transport System y/ / High-Throughput Screening Assays Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Animals / Humans Language: En Journal: ACS Chem Biol Year: 2017 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos