Temporal variations in early developmental decisions: an engine of forebrain evolution.
Curr Opin Neurobiol
; 42: 152-159, 2017 02.
Article
in En
| MEDLINE
| ID: mdl-28092740
ABSTRACT
Tight control of developmental timing is pivotal to many major processes in developmental biology, such as patterning, fate specification, cell cycle dynamics, cell migration and connectivity. Temporal change in these ontogenetic sequences is known as heterochrony, a major force in the evolution of body plans and organogenesis. In the last 5 years, studies in fish and rodents indicate that heterochrony in signaling during early development generates diversity in forebrain size and complexity. Here, we summarize these findings and propose that, additionally to spatio-temporal tuning of neurogenesis, temporal and quantitative modulation of signaling events drive pivotal changes in shape, size and complexity of the forebrain across evolution, participating to the generation of diversity in animal behavior and emergence of cognition.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prosencephalon
/
Biological Evolution
/
Neurogenesis
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Curr Opin Neurobiol
Journal subject:
BIOLOGIA
/
NEUROLOGIA
Year:
2017
Document type:
Article
Affiliation country:
Reino Unido