Liver physiological polyploidization: MicroRNA-122 a key regulator.
Clin Res Hepatol Gastroenterol
; 41(2): 123-125, 2017 Mar.
Article
in En
| MEDLINE
| ID: mdl-28139382
ABSTRACT
Polyploidy is defined as an increase in genome DNA content and is observed in all mammalian species. Polyploidy is a common characteristic of hepatocytes. Polyploidization occurs mainly during liver development, but also in adults with increasing age or due to cellular stress. During liver development, hepatocytes polyploidization occurs through cytokinesis failure leading to the genesis of binucleate hepatocytes. Recently, Hsu et al. demonstrated that miR-122 is a key regulator of hepatic binucleation. In fact, during liver development, miR-122 directly antagonizes procytokinesis targets and thus induces cytokinesis failure leading to the genesis of binucleate hepatocytes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polyploidy
/
Hepatocytes
/
MicroRNAs
/
Liver
Limits:
Animals
/
Humans
Language:
En
Journal:
Clin Res Hepatol Gastroenterol
Year:
2017
Document type:
Article
Affiliation country:
Francia