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Phosphinophosphonates and Their Tris-pivaloyloxymethyl Prodrugs Reveal a Negatively Cooperative Butyrophilin Activation Mechanism.
Shippy, Rebekah R; Lin, Xiaochen; Agabiti, Sherry S; Li, Jin; Zangari, Brendan M; Foust, Benjamin J; Poe, Michael M; Hsiao, Chia-Hung Christine; Vinogradova, Olga; Wiemer, David F; Wiemer, Andrew J.
Affiliation
  • Shippy RR; Department of Chemistry, University of Iowa , Iowa City, Iowa 52242, United States.
  • Lin X; Department of Pharmaceutical Sciences, University of Connecticut , Storrs, Connecticut 06269, United States.
  • Agabiti SS; Department of Pharmaceutical Sciences, University of Connecticut , Storrs, Connecticut 06269, United States.
  • Li J; Department of Pharmaceutical Sciences, University of Connecticut , Storrs, Connecticut 06269, United States.
  • Zangari BM; Department of Pharmaceutical Sciences, University of Connecticut , Storrs, Connecticut 06269, United States.
  • Foust BJ; Department of Chemistry, University of Iowa , Iowa City, Iowa 52242, United States.
  • Poe MM; Department of Pharmaceutical Sciences, University of Connecticut , Storrs, Connecticut 06269, United States.
  • Hsiao CC; Department of Pharmaceutical Sciences, University of Connecticut , Storrs, Connecticut 06269, United States.
  • Vinogradova O; Department of Pharmaceutical Sciences, University of Connecticut , Storrs, Connecticut 06269, United States.
  • Wiemer DF; Department of Chemistry, University of Iowa , Iowa City, Iowa 52242, United States.
  • Wiemer AJ; Department of Pharmaceutical Sciences, University of Connecticut , Storrs, Connecticut 06269, United States.
J Med Chem ; 60(6): 2373-2382, 2017 03 23.
Article in En | MEDLINE | ID: mdl-28218845
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prodrugs / Antigens, CD / Organophosphonates / Butyrophilins Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2017 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prodrugs / Antigens, CD / Organophosphonates / Butyrophilins Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2017 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos