Clonidine may have a beneficial effect on refractory nocturnal enuresis.
Pediatr Int
; 59(6): 711-713, 2017 Jun.
Article
in En
| MEDLINE
| ID: mdl-28235147
ABSTRACT
BACKGROUND:
Although the evidence-based treatment for nocturnal enuresis is established, nearly one-third of patients are still enuretic with desmopressin, anti-cholinergic treatment and alarm. The fourth option, imipramine, is limited because of the risk of cardiotoxicity on overdose. Clonidine, an α2 -adrenoceptor agonist that also has noradrenergic effects like imipramine, is a new option for refractory enuresis.METHODS:
A total of 148 patients (6-14 years of age; mean, 9.1 years) with refractory enuresis under desmopressin, anti-cholinergic treatment and alarm were enrolled. The patients consisted of 100 boys and 48 girls, of whom 23 had monosymptomatic nocturnal enuresis and 125 had non-monosymptomatic nocturnal enuresis. Clonidine 4 µg/kg/day (maximum, 75 µg/day) orally 30 min before bedtime was added and its effects were evaluated after 4 weeks of treatment.RESULTS:
A total of 83 patients (56.1%) achieved partial or complete response with the additional clonidine. No significant adverse reactions were noted.CONCLUSIONS:
Clonidine could be an aid for refractory enuresis, although further randomized controlled trials are needed.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Clonidine
/
Nocturnal Enuresis
/
Adrenergic alpha-2 Receptor Agonists
Type of study:
Clinical_trials
Limits:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Language:
En
Journal:
Pediatr Int
Journal subject:
PEDIATRIA
Year:
2017
Document type:
Article
Affiliation country:
Japón
Publication country:
AU
/
AUSTRALIA
/
AUSTRÁLIA