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Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice.
Pakavathkumar, Prateep; Noël, Anastasia; Lecrux, Clotilde; Tubeleviciute-Aydin, Agne; Hamel, Edith; Ahlfors, Jan-Eric; LeBlanc, Andrea C.
Affiliation
  • Pakavathkumar P; Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, 3999 Ch. Cote Ste-Catherine, Montreal, QC, H3T 1E2, Canada.
  • Noël A; Department of Neurology and Neurosurgery, McGill University, 845 Sherbrooke O, Montreal, QC, H3A 0G4, Canada.
  • Lecrux C; Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, 3999 Ch. Cote Ste-Catherine, Montreal, QC, H3T 1E2, Canada.
  • Tubeleviciute-Aydin A; Department of Neurology and Neurosurgery, McGill University, 845 Sherbrooke O, Montreal, QC, H3A 0G4, Canada.
  • Hamel E; Laboratory of Cerebrovascular Research, Montreal Neurological Institute, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
  • Ahlfors JE; Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, 3999 Ch. Cote Ste-Catherine, Montreal, QC, H3T 1E2, Canada.
  • LeBlanc AC; Department of Neurology and Neurosurgery, McGill University, 845 Sherbrooke O, Montreal, QC, H3A 0G4, Canada.
Mol Neurodegener ; 12(1): 22, 2017 02 28.
Article in En | MEDLINE | ID: mdl-28241839
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfones / Neuroprotective Agents / Caspase 6 / Caspase Inhibitors / Nerve Degeneration / Neurons Limits: Animals / Humans Language: En Journal: Mol Neurodegener Year: 2017 Document type: Article Affiliation country: Canadá
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfones / Neuroprotective Agents / Caspase 6 / Caspase Inhibitors / Nerve Degeneration / Neurons Limits: Animals / Humans Language: En Journal: Mol Neurodegener Year: 2017 Document type: Article Affiliation country: Canadá