Combination of thioridazine and dicloxacillin as a possible treatment strategy of staphylococci.
New Microbiol
; 40(2): 146-147, 2017 Apr.
Article
in En
| MEDLINE
| ID: mdl-28255602
ABSTRACT
We have previously shown that the phenothiazine, thioridazine, acts in synergy with the beta-lactam antibiotic, dicloxacillin, to kill methicillin-resistant Staphylococcus aureus. In this study, we investigated whether synergy by combining these two drugs could also be observed in vancomycin intermediate susceptible S. aureus (VISA) and methicillin-resistant Staphylococcus epidermidis (MRSE). Synergy was observed in three of four tested VISA strains, suggesting that the thickening of cell wall does not interfere with the effects of thioridazine. In S. epidermidis, no synergy was observed in all tested strains, suggesting that synergy by combining thioridazine and dicloxacillin is isolated to S. aureus species.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Staphylococcal Infections
/
Staphylococcus aureus
/
Staphylococcus epidermidis
/
Thioridazine
/
Dicloxacillin
/
Anti-Bacterial Agents
Limits:
Humans
Language:
En
Journal:
New Microbiol
Journal subject:
MICROBIOLOGIA
Year:
2017
Document type:
Article
Affiliation country:
Dinamarca