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Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.
Waldschmidt, Helen V; Homan, Kristoff T; Cato, Marilyn C; Cruz-Rodríguez, Osvaldo; Cannavo, Alessandro; Wilson, Michael W; Song, Jianliang; Cheung, Joseph Y; Koch, Walter J; Tesmer, John J G; Larsen, Scott D.
Affiliation
  • Waldschmidt HV; Department of Medicinal Chemistry, College of Pharmacy, ‡Departments of Pharmacology and Biological Chemistry, Life Sciences Institute, §Ph.D. Program in Chemical Biology, ⊥Vahlteich Medicinal Chemistry Core, University of Michigan , Ann Arbor, Michigan 48109, United States.
  • Homan KT; Center for Translational Medicine, Temple University , Philadelphia, Pennsylvania 19140, United States.
  • Cato MC; Department of Medicinal Chemistry, College of Pharmacy, ‡Departments of Pharmacology and Biological Chemistry, Life Sciences Institute, §Ph.D. Program in Chemical Biology, ⊥Vahlteich Medicinal Chemistry Core, University of Michigan , Ann Arbor, Michigan 48109, United States.
  • Cruz-Rodríguez O; Center for Translational Medicine, Temple University , Philadelphia, Pennsylvania 19140, United States.
  • Cannavo A; Department of Medicinal Chemistry, College of Pharmacy, ‡Departments of Pharmacology and Biological Chemistry, Life Sciences Institute, §Ph.D. Program in Chemical Biology, ⊥Vahlteich Medicinal Chemistry Core, University of Michigan , Ann Arbor, Michigan 48109, United States.
  • Wilson MW; Center for Translational Medicine, Temple University , Philadelphia, Pennsylvania 19140, United States.
  • Song J; Department of Medicinal Chemistry, College of Pharmacy, ‡Departments of Pharmacology and Biological Chemistry, Life Sciences Institute, §Ph.D. Program in Chemical Biology, ⊥Vahlteich Medicinal Chemistry Core, University of Michigan , Ann Arbor, Michigan 48109, United States.
  • Cheung JY; Center for Translational Medicine, Temple University , Philadelphia, Pennsylvania 19140, United States.
  • Koch WJ; Department of Medicinal Chemistry, College of Pharmacy, ‡Departments of Pharmacology and Biological Chemistry, Life Sciences Institute, §Ph.D. Program in Chemical Biology, ⊥Vahlteich Medicinal Chemistry Core, University of Michigan , Ann Arbor, Michigan 48109, United States.
  • Tesmer JJ; Center for Translational Medicine, Temple University , Philadelphia, Pennsylvania 19140, United States.
  • Larsen SD; Department of Medicinal Chemistry, College of Pharmacy, ‡Departments of Pharmacology and Biological Chemistry, Life Sciences Institute, §Ph.D. Program in Chemical Biology, ⊥Vahlteich Medicinal Chemistry Core, University of Michigan , Ann Arbor, Michigan 48109, United States.
J Med Chem ; 60(7): 3052-3069, 2017 04 13.
Article in En | MEDLINE | ID: mdl-28323425
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Paroxetine / Protein Kinase Inhibitors / G-Protein-Coupled Receptor Kinase 2 Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2017 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Paroxetine / Protein Kinase Inhibitors / G-Protein-Coupled Receptor Kinase 2 Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2017 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos