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Phenotypic characterization of regulatory T cells from antiretroviral-naive HIV-1-infected people.
Ambada, Georgia N; Ntsama, Claudine E; Nji, Nadesh N; Ngu, Loveline N; Sake, Carole N; Lissom, Abel; Tchouangeu, Flaurent T; Tchadji, Jules; Sosso, Martin; Etoa, François-Xavier; Nchinda, Godwin W.
Affiliation
  • Ambada GN; Laboratory of Vaccinology/Biobanking, the Chantal Biya International Reference Centre for Research on the Prevention and Management of HIV/AIDS, Yaounde, Cameroon.
  • Ntsama CE; Department of Animal Biology and Physiology, Faculty of Sciences, University of Yaounde one, Yaounde, Cameroon.
  • Nji NN; Department of Animal Biology and Physiology, Faculty of Sciences, University of Yaounde one, Yaounde, Cameroon.
  • Ngu LN; Laboratory of Vaccinology/Biobanking, the Chantal Biya International Reference Centre for Research on the Prevention and Management of HIV/AIDS, Yaounde, Cameroon.
  • Sake CN; Laboratory of Vaccinology/Biobanking, the Chantal Biya International Reference Centre for Research on the Prevention and Management of HIV/AIDS, Yaounde, Cameroon.
  • Lissom A; Department of Biochemistry, Faculty of Sciences, University of Yaounde one, Yaounde, Cameroon.
  • Tchouangeu FT; Laboratory of Vaccinology/Biobanking, the Chantal Biya International Reference Centre for Research on the Prevention and Management of HIV/AIDS, Yaounde, Cameroon.
  • Tchadji J; Department of Biochemistry, Faculty of Sciences, University of Yaounde one, Yaounde, Cameroon.
  • Sosso M; Laboratory of Vaccinology/Biobanking, the Chantal Biya International Reference Centre for Research on the Prevention and Management of HIV/AIDS, Yaounde, Cameroon.
  • Etoa FX; Department of Animal Biology and Physiology, Faculty of Sciences, University of Yaounde one, Yaounde, Cameroon.
  • Nchinda GW; Laboratory of Vaccinology/Biobanking, the Chantal Biya International Reference Centre for Research on the Prevention and Management of HIV/AIDS, Yaounde, Cameroon.
Immunology ; 151(4): 405-416, 2017 08.
Article in En | MEDLINE | ID: mdl-28375551
Regulatory T (Treg) cells play a key role in dampening excessive immune activation. However, antiretroviral therapy (ART) -naive HIV-1 infection maintains the immune system in a sustained state of activation that could alter both Treg cell surface markers and functions. As Treg cell surface markers are directly linked to their functions the overall objective of this study was to determine how ART-naive HIV infection affects the phenotypic properties of Treg cells. Our data showed that in ART-naive HIV-1 infection, Treg cells are dominated by effector (CD45RA+  CD27-  CCR7- CD62L- ) and effector memory (CD45RA-  CD27-  CCR7-  CD62L- ) cells. In contrast Treg cells from HIV-negative individuals were mainly naive (CD45RA+  CD27+  CCR7+  CD62L+ ) and central memory (CD45RA- CD27+  CCR7+  CD62L+ ) cells. Whereas effector and effector memory Treg cells showed enhanced expression of CD39 (P < 0·05), CD73 (P < 0·001), HLA-DR and CD38 (P < 0·001); naive and central memory Treg cells showed a significant reduction in the expression of these markers. Overall Treg cell frequencies within total CD4+ T cells correlated positively with plasmatic HIV-1 viral load. As increased viral load is associated with augmented CD4+ T-cell destruction; this could suggest a resistance of peripheral Treg cells to HIV-1 destruction. Hence the modulation of Treg cell phenotype and frequencies could be considered in designing immunotherapeutic strategies targeting immune system restoration during HIV-1 infection.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / Immunotherapy, Adoptive / T-Lymphocyte Subsets / HIV-1 / T-Lymphocytes, Regulatory Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Africa Language: En Journal: Immunology Year: 2017 Document type: Article Affiliation country: Camerún Country of publication: Reino Unido

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / Immunotherapy, Adoptive / T-Lymphocyte Subsets / HIV-1 / T-Lymphocytes, Regulatory Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Africa Language: En Journal: Immunology Year: 2017 Document type: Article Affiliation country: Camerún Country of publication: Reino Unido