Liver transplantation for drug-induced acute liver failure.
Eur Rev Med Pharmacol Sci
; 21(1 Suppl): 37-45, 2017 03.
Article
in En
| MEDLINE
| ID: mdl-28379596
ABSTRACT
OBJECTIVES:
To summarize the different clinical features of drug-induced acute liver failure, the diagnostic work-up, conservative management and the prognostic scores currently used to list patients for liver transplantation. EVIDENCE AND INFORMATION SOURCES The current review is based on an analysis of the current literature and the caseload experience of the Authors on this topic. STATE OF THE ART Drug-induced liver injury is the leading cause of acute liver failure in the adult population in Western countries, with a transplant-free survival rate of less than 50%. Main subtypes include paracetamol and idiosyncratic drug-induced injury, which differ in epidemiology, clinical course, prognosis and conservative management. In cases of a high likelihood of death, urgent hepatic transplantation is indicated, but the decision whether and when to put a patient with drug-induced acute liver failure on the list for urgent liver transplant is extremely difficult and requires constant interdisciplinary exchange and continuous updating of the clinical picture.CONCLUSIONS:
Intensive management should be done in a clinical tertiary referral center which has a specialized team of hepatologists and a liver transplant center.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Liver Transplantation
/
Liver Failure, Acute
/
Acetaminophen
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Eur Rev Med Pharmacol Sci
Journal subject:
FARMACOLOGIA
/
TOXICOLOGIA
Year:
2017
Document type:
Article
Affiliation country:
Italia