Post-liver transplant intrahepatic cholestasis: etiology, clinical presentation, therapy.
Eur Rev Med Pharmacol Sci
; 21(1 Suppl): 23-36, 2017 03.
Article
in En
| MEDLINE
| ID: mdl-28379597
ABSTRACT
Post-liver transplant intrahepatic cholestasis is consequent to the impairment of bile flow or formation. It may develop in the early (within 6 months) or in the late (more than 6 months) post-liver transplant period and different causes may be recognized according to the time elapsed from a liver transplant. The raise at various degrees of serum bilirubin, alkaline phosphatase, and gamma-glutamyl transpeptidase, with or without increased transaminases levels, are common hematochemical findings. Liver histology is helpful for diagnostic assessment, and sometimes crucial to differentiate among possible causes of cholestasis. Although timely treatment of underling conditions as well as supportive care may resolve post-liver transplant intrahepatic cholestasis, the risk of graft loss and retransplantation are remarkable. For this reason, post-liver transplant intrahepatic cholestasis should be managed in collaboration with the LT center, and treatment should be devolved to expert hepatologists.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Reoperation
/
Cholestasis, Intrahepatic
/
Liver Transplantation
Type of study:
Etiology_studies
Limits:
Humans
Language:
En
Journal:
Eur Rev Med Pharmacol Sci
Journal subject:
FARMACOLOGIA
/
TOXICOLOGIA
Year:
2017
Document type:
Article
Affiliation country:
Italia
Publication country:
IT
/
ITALIA
/
ITALY
/
ITÁLIA