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Developing DYRK inhibitors derived from the meridianins as a means of increasing levels of NFAT in the nucleus.
Shaw, Simon J; Goff, Dane A; Lin, Nan; Singh, Rajinder; Li, Wei; McLaughlin, John; Baltgalvis, Kristen A; Payan, Donald G; Kinsella, Todd M.
Affiliation
  • Shaw SJ; Rigel Pharmaceuticals, Inc., 1180, Veterans Boulevard, South San Francisco, CA 94080, USA. Electronic address: sshaw@rigel.com.
  • Goff DA; Rigel Pharmaceuticals, Inc., 1180, Veterans Boulevard, South San Francisco, CA 94080, USA.
  • Lin N; Rigel Pharmaceuticals, Inc., 1180, Veterans Boulevard, South San Francisco, CA 94080, USA.
  • Singh R; Rigel Pharmaceuticals, Inc., 1180, Veterans Boulevard, South San Francisco, CA 94080, USA.
  • Li W; Rigel Pharmaceuticals, Inc., 1180, Veterans Boulevard, South San Francisco, CA 94080, USA.
  • McLaughlin J; Rigel Pharmaceuticals, Inc., 1180, Veterans Boulevard, South San Francisco, CA 94080, USA.
  • Baltgalvis KA; Rigel Pharmaceuticals, Inc., 1180, Veterans Boulevard, South San Francisco, CA 94080, USA.
  • Payan DG; Rigel Pharmaceuticals, Inc., 1180, Veterans Boulevard, South San Francisco, CA 94080, USA.
  • Kinsella TM; Rigel Pharmaceuticals, Inc., 1180, Veterans Boulevard, South San Francisco, CA 94080, USA.
Bioorg Med Chem Lett ; 27(11): 2617-2621, 2017 06 01.
Article in En | MEDLINE | ID: mdl-28408219
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Cell Nucleus / Protein Serine-Threonine Kinases / Indole Alkaloids / Protein Kinase Inhibitors / NFATC Transcription Factors Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2017 Document type: Article Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Cell Nucleus / Protein Serine-Threonine Kinases / Indole Alkaloids / Protein Kinase Inhibitors / NFATC Transcription Factors Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2017 Document type: Article Country of publication: Reino Unido