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Opposite effects of GCN5 and PCAF knockdowns on the alternative mechanism of telomere maintenance.
Jeitany, Maya; Bakhos-Douaihy, Dalal; Silvestre, David C; Pineda, Jose R; Ugolin, Nicolas; Moussa, Angela; Gauthier, Laurent R; Busso, Didier; Junier, Marie-Pierre; Chneiweiss, Hervé; Chevillard, Sylvie; Desmaze, Chantal; Boussin, François D.
Affiliation
  • Jeitany M; Laboratoire de Radiopathologie, CEA, Institut de Radiobiologie Cellulaire et Moléculaire, Fontenay-aux-Roses, France.
  • Bakhos-Douaihy D; INSERM UMR967, Fontenay-aux-Roses, France.
  • Silvestre DC; Université Paris VII, UMR967, Fontenay-aux-Roses, France.
  • Pineda JR; Université Paris XI, UMR967, Fontenay-aux-Roses, France.
  • Ugolin N; Laboratoire de Radiopathologie, CEA, Institut de Radiobiologie Cellulaire et Moléculaire, Fontenay-aux-Roses, France.
  • Moussa A; INSERM UMR967, Fontenay-aux-Roses, France.
  • Gauthier LR; Université Paris VII, UMR967, Fontenay-aux-Roses, France.
  • Busso D; Université Paris XI, UMR967, Fontenay-aux-Roses, France.
  • Junier MP; Laboratoire de Radiopathologie, CEA, Institut de Radiobiologie Cellulaire et Moléculaire, Fontenay-aux-Roses, France.
  • Chneiweiss H; INSERM UMR967, Fontenay-aux-Roses, France.
  • Chevillard S; Université Paris VII, UMR967, Fontenay-aux-Roses, France.
  • Desmaze C; Université Paris XI, UMR967, Fontenay-aux-Roses, France.
  • Boussin FD; Laboratoire de Radiopathologie, CEA, Institut de Radiobiologie Cellulaire et Moléculaire, Fontenay-aux-Roses, France.
Oncotarget ; 8(16): 26269-26280, 2017 Apr 18.
Article in En | MEDLINE | ID: mdl-28412741
ABSTRACT
Cancer cells can use a telomerase-independent mechanism, known as alternative lengthening of telomeres (ALT), to elongate their telomeres. General control non-derepressible 5 (GCN5) and P300/CBP-associated factor (PCAF) are two homologous acetyltransferases that are mutually exclusive subunits in SAGA-like complexes. Here, we reveal that down regulation of GCN5 and PCAF had differential effects on some phenotypic characteristics of ALT cells. Our results suggest that GCN5 is present at telomeres and opposes telomere recombination, in contrast to PCAF that may indirectly favour them in ALT cells.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Telomere / P300-CBP Transcription Factors / Genetic Association Studies / Telomere Homeostasis Type of study: Prognostic_studies Limits: Humans Language: En Journal: Oncotarget Year: 2017 Document type: Article Affiliation country: Francia
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Telomere / P300-CBP Transcription Factors / Genetic Association Studies / Telomere Homeostasis Type of study: Prognostic_studies Limits: Humans Language: En Journal: Oncotarget Year: 2017 Document type: Article Affiliation country: Francia