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High expression of miR-125b-2 and SNORD116 noncoding RNA clusters characterize ERG-related B cell precursor acute lymphoblastic leukemia.
Vendramini, Elena; Giordan, Marco; Giarin, Emanuela; Michielotto, Barbara; Fazio, Grazia; Cazzaniga, Gianni; Biondi, Andrea; Silvestri, Daniela; Valsecchi, Maria Grazia; Muckenthaler, Martina U; Kulozik, Andreas E; Gattei, Valter; Izraeli, Shai; Basso, Giuseppe; Te Kronnie, Geertruy.
Affiliation
  • Vendramini E; Department of Women's and Children's Health, University of Padova, Padova, Italy.
  • Giordan M; Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel.
  • Giarin E; Tel Aviv University, Tel Aviv, Israel.
  • Michielotto B; Department of Women's and Children's Health, University of Padova, Padova, Italy.
  • Fazio G; Department of Women's and Children's Health, University of Padova, Padova, Italy.
  • Cazzaniga G; Department of Women's and Children's Health, University of Padova, Padova, Italy.
  • Biondi A; Centro Ricerca Tettamanti, Clinica Pediatrica, University of Milano-Bicocca, Monza, Italy.
  • Silvestri D; Centro Ricerca Tettamanti, Clinica Pediatrica, University of Milano-Bicocca, Monza, Italy.
  • Valsecchi MG; Centro Ricerca Tettamanti, Clinica Pediatrica, University of Milano-Bicocca, Monza, Italy.
  • Muckenthaler MU; Centro Ricerca Tettamanti, Clinica Pediatrica, University of Milano-Bicocca, Monza, Italy.
  • Kulozik AE; School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.
  • Gattei V; Department of Pediatric Oncology Hematology, University of Heidelberg, Heidelberg, Germany.
  • Izraeli S; Department of Pediatric Oncology Hematology, University of Heidelberg, Heidelberg, Germany.
  • Basso G; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, I.R.C.C.S., Aviano (PN), Italy.
  • Te Kronnie G; Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel.
Oncotarget ; 8(26): 42398-42413, 2017 Jun 27.
Article in En | MEDLINE | ID: mdl-28415578
ERG-related leukemia is a B cell precursor acute lymphoblastic leukemia (BCP ALL) subtype characterized by aberrant expression of DUX4 and ERG transcription factors, and highly recurrent ERG intragenic deletions. ERG-related patients have remarkably favorable outcome despite a high incidence of inauspicious IKZF1 aberrations.We describe clinical and genomic features of the ERG-related cases in an unselected cohort of B-other BCP ALL pediatric patients enrolled in the AIEOP ALL 2000 therapeutic protocol. We report a small noncoding RNA signature specific of ERG-related group, with up-regulation of miR-125b-2 cluster on chromosome 21 and several snoRNAs in the Prader-Willi locus at 15q11.2, including the orphan SNORD116 cluster.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Gene Expression / Multigene Family / RNA, Small Nucleolar / MicroRNAs / Transcriptional Regulator ERG Type of study: Etiology_studies / Guideline / Incidence_studies / Observational_studies / Risk_factors_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Language: En Journal: Oncotarget Year: 2017 Document type: Article Affiliation country: Italia Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Gene Expression / Multigene Family / RNA, Small Nucleolar / MicroRNAs / Transcriptional Regulator ERG Type of study: Etiology_studies / Guideline / Incidence_studies / Observational_studies / Risk_factors_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Language: En Journal: Oncotarget Year: 2017 Document type: Article Affiliation country: Italia Country of publication: Estados Unidos