Long-term calorie restriction in humans is not associated with indices of delayed immunologic aging: A descriptive study.
Nutr Healthy Aging
; 4(2): 147-156, 2017 Mar 31.
Article
in En
| MEDLINE
| ID: mdl-28447069
ABSTRACT
BACKGROUND:
Delayed immunologic aging is purported to be a major mechanism through which calorie restriction (CR) exerts its anti-aging effects in non-human species. However, in non-obese humans, the effect of CR on the immune system has been understudied relative to its effects on the cardiometabolic system.OBJECTIVE:
To examine whether CR is associated with delayed immunologic aging in non-obese humans.METHODS:
We tested whether long-term CR practitioners (average 10.03 years of CR) evidenced decreased expression of T cell immunosenescence markers and longer immune cell telomeres compared to gender-, race/ethnicity-, age-, and education-matched "healthy" Body Mass Index (BMI) and "overweight"/"obese" BMI groups.RESULTS:
Long-term human CR practitioners had lower BMI (pâ<â 0.001) and fasting glucose (pâ<â 0.001), as expected. They showed similar frequencies of pre-senescent cells (CD8+CD28- T cells and CD57 and PD-1 expressing T cells) to the comparison groups. Even after adjusting for covariates, including cytomegalovirus status, we observed shorter peripheral blood mononuclear cell telomeres in the CR group (pâ=â0.012) and no difference in granulocyte telomeres between groups (pâ=â0.42).CONCLUSIONS:
We observed no clear evidence that CR as it is currently practiced in humans delays immune aging related to telomere length or T cell immunosenescent markers.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Prognostic_studies
/
Risk_factors_studies
Language:
En
Journal:
Nutr Healthy Aging
Year:
2017
Document type:
Article
Affiliation country:
Estados Unidos
Publication country:
HOLANDA
/
HOLLAND
/
NETHERLANDS
/
NL
/
PAISES BAJOS
/
THE NETHERLANDS