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Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab.
Ramagopal, Udupi A; Liu, Weifeng; Garrett-Thomson, Sarah C; Bonanno, Jeffrey B; Yan, Qingrong; Srinivasan, Mohan; Wong, Susan C; Bell, Alasdair; Mankikar, Shilpa; Rangan, Vangipuram S; Deshpande, Shrikant; Korman, Alan J; Almo, Steven C.
Affiliation
  • Ramagopal UA; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461.
  • Liu W; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461.
  • Garrett-Thomson SC; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
  • Bonanno JB; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461.
  • Yan Q; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461.
  • Srinivasan M; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
  • Wong SC; Biologics Discovery California, Bristol-Myers Squibb, Redwood City, CA 94063.
  • Bell A; Biologics Discovery California, Bristol-Myers Squibb, Redwood City, CA 94063.
  • Mankikar S; Biologics Discovery California, Bristol-Myers Squibb, Redwood City, CA 94063.
  • Rangan VS; Biologics Discovery California, Bristol-Myers Squibb, Redwood City, CA 94063.
  • Deshpande S; Biologics Discovery California, Bristol-Myers Squibb, Redwood City, CA 94063.
  • Korman AJ; Biologics Discovery California, Bristol-Myers Squibb, Redwood City, CA 94063.
  • Almo SC; Biologics Discovery California, Bristol-Myers Squibb, Redwood City, CA 94063 steve.almo@einstein.yu.edu alan.korman@bms.com.
Proc Natl Acad Sci U S A ; 114(21): E4223-E4232, 2017 05 23.
Article in En | MEDLINE | ID: mdl-28484017

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Binding Sites, Antibody / CTLA-4 Antigen / Ipilimumab / Antineoplastic Agents, Immunological / Melanoma / Antigen-Antibody Complex Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2017 Document type: Article Country of publication: Estados Unidos

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Binding Sites, Antibody / CTLA-4 Antigen / Ipilimumab / Antineoplastic Agents, Immunological / Melanoma / Antigen-Antibody Complex Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2017 Document type: Article Country of publication: Estados Unidos