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Atropisomerism and Conformational Equilibria: Impact on PI3Kδ Inhibition of 2-((6-Amino-9H-purin-9-yl)methyl)-5-methyl-3-(o-tolyl)quinazolin-4(3H)-one (IC87114) and Its Conformationally Restricted Analogs.
Lodola, Alessio; Bertolini, Serena; Biagetti, Matteo; Capacchi, Silvia; Facchinetti, Fabrizio; Gallo, Paola Maria; Pappani, Alice; Mor, Marco; Pala, Daniele; Rivara, Silvia; Visentini, Filippo; Corsi, Mauro; Capelli, Anna Maria.
Affiliation
  • Lodola A; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma , Viale delle Scienze 27/A, 43124 Parma, Italy.
  • Bertolini S; Chemistry Research and Drug Design Department, Chiesi Farmaceutici S.p.A. , Largo F. Belloli 11/A, 43122 Parma, Italy.
  • Biagetti M; Chemistry Research and Drug Design Department, Chiesi Farmaceutici S.p.A. , Largo F. Belloli 11/A, 43122 Parma, Italy.
  • Capacchi S; Chemistry Research and Drug Design Department, Chiesi Farmaceutici S.p.A. , Largo F. Belloli 11/A, 43122 Parma, Italy.
  • Facchinetti F; Chemistry Research and Drug Design Department, Chiesi Farmaceutici S.p.A. , Largo F. Belloli 11/A, 43122 Parma, Italy.
  • Gallo PM; Chemistry Research and Drug Design Department, Chiesi Farmaceutici S.p.A. , Largo F. Belloli 11/A, 43122 Parma, Italy.
  • Pappani A; Chemistry Research and Drug Design Department, Chiesi Farmaceutici S.p.A. , Largo F. Belloli 11/A, 43122 Parma, Italy.
  • Mor M; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma , Viale delle Scienze 27/A, 43124 Parma, Italy.
  • Pala D; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma , Viale delle Scienze 27/A, 43124 Parma, Italy.
  • Rivara S; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma , Viale delle Scienze 27/A, 43124 Parma, Italy.
  • Visentini F; Aptuit s.r.l. , Via Fleming 4, 37135 Verona, Italy.
  • Corsi M; Aptuit s.r.l. , Via Fleming 4, 37135 Verona, Italy.
  • Capelli AM; Chemistry Research and Drug Design Department, Chiesi Farmaceutici S.p.A. , Largo F. Belloli 11/A, 43122 Parma, Italy.
J Med Chem ; 60(10): 4304-4315, 2017 05 25.
Article in En | MEDLINE | ID: mdl-28489362
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / Adenine / Protein Kinase Inhibitors / Phosphoinositide-3 Kinase Inhibitors Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2017 Document type: Article Affiliation country: Italia Country of publication: Estados Unidos
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / Adenine / Protein Kinase Inhibitors / Phosphoinositide-3 Kinase Inhibitors Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2017 Document type: Article Affiliation country: Italia Country of publication: Estados Unidos