Transgenic autoinhibition of p21-activated kinase exacerbates synaptic impairments and fronto-dependent behavioral deficits in an animal model of Alzheimer's disease.

Bories, Cyril; Arsenault, Dany; Lemire, Myriam; Tremblay, Cyntia; De Koninck, Yves; Calon, Frédéric

Bories, Cyril; Arsenault, Dany; Lemire, Myriam; Tremblay, Cyntia; De Koninck, Yves; Calon, Frédéric.

Affiliation

Bories C; Research Center of Institut Universitaire en Santé Mentale de Québec, Quebec City, QC, Canada.
Arsenault D; Faculty of Pharmacy Laval University, Quebec City, QC, Canada.
Lemire M; Centre Hospitalier de l'Université Laval (CHUL) Research Center, Quebec City, QC, Canada.
Tremblay C; Research Center of Institut Universitaire en Santé Mentale de Québec, Quebec City, QC, Canada.
De Koninck Y; Faculty of Pharmacy Laval University, Quebec City, QC, Canada.
Calon F; Centre Hospitalier de l'Université Laval (CHUL) Research Center, Quebec City, QC, Canada.

Aging (Albany NY) ; 9(5): 1386-1403, 2017 05 16.

Article in En | MEDLINE | ID: mdl-28522792

Subject(s)
Key words

3xTg-AD mice; Alzheimer; electrophysiology; frontal cortex; morphology; p21-activated kinase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Behavior, Animal / Pyramidal Cells / P21-Activated Kinases / Alzheimer Disease / Frontal Lobe Limits: Animals Language: En Journal: Aging (Albany NY) Journal subject: GERIATRIA Year: 2017 Document type: Article Affiliation country: Canadá Country of publication: Estados Unidos

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