Direct medical costs of severe hypoglycaemic events in patients with type 2 diabetes in England: A retrospective database study.
Int J Clin Pract
; 71(6)2017 Jun.
Article
in En
| MEDLINE
| ID: mdl-28544081
ABSTRACT
AIMS:
Hypoglycaemia in patients with diabetes can be induced by insulins and sulfonylureas. We assessed the real-world impact of specific monotherapy and combination regimens on hypoglycaemic events requiring hospitalisation and related secondary costs to the English healthcare system.METHODS:
This retrospective observational study used the Clinical Practice Research Datalink with linked hospital admission data during 2008-2012. Patients with type 2 diabetes mellitus (T2DM) using antihyperglycaemic agents (AHAs) were assigned to mutually exclusive subgroups (insulin- and non-insulin-containing regimens; treatment groups of interest; age group) based on treatment at index date (date of first AHA prescription). Outcomes were number and cost of hospital admissions with hypoglycaemic event-related diagnosis codes.RESULTS:
We identified 110 206 patients with T2DM (mean age 64.9 years, time since diagnosis 5.4 years, HbA1c at index 7.4%), with 439 hypoglycaemic events requiring inpatient hospitalisation (mean length of stay 6.3 days, mean cost/stay £1351). Event rates and cost of stay were highest in patients treated with sulfonylurea- or insulin-based regimens. Event rates, duration and cost of stay were higher in older patients.CONCLUSION:
Rates of severe hypoglycaemic events varied substantially between T2DM regimens. In this study of patients treated in clinical practice in England, sulfonylurea- and insulin-based regimens were associated with the highest event rates and costs associated with hospitalisation for severe hypoglycaemic events; hospitalisation for severe hypoglycaemic events was not observed with dipeptidyl peptidase-4 inhibitor monotherapy or with metformin.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Health Care Costs
/
Diabetes Mellitus, Type 2
/
Hypoglycemia
Type of study:
Health_economic_evaluation
/
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
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Female
/
Humans
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Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
Int J Clin Pract
Journal subject:
MEDICINA
Year:
2017
Document type:
Article
Affiliation country:
Reino Unido
Publication country:
IN
/
INDIA
/
ÍNDIA