Structure-activity relationships for flavone interactions with amyloid ß reveal a novel anti-aggregatory and neuroprotective effect of 2',3',4'-trihydroxyflavone (2-D08).

Marsh, Dylan T; Das, Sukanya; Ridell, Jessica; Smid, Scott D

Marsh, Dylan T; Das, Sukanya; Ridell, Jessica; Smid, Scott D.

Affiliation

Marsh DT; Discipline of Pharmacology, School of Medical Sciences, Faculty of Health Sciences, The University of Adelaide, South Australia, Australia.
Das S; Discipline of Pharmacology, School of Medical Sciences, Faculty of Health Sciences, The University of Adelaide, South Australia, Australia.
Ridell J; Institute of Neuroscience and Physiology, The Sahlgrenska Academy, Göteborg University, Sweden.
Smid SD; Discipline of Pharmacology, School of Medical Sciences, Faculty of Health Sciences, The University of Adelaide, South Australia, Australia. Electronic address: scott.smid@adelaide.edu.au.

Bioorg Med Chem ; 25(14): 3827-3834, 2017 07 15.

Article in En | MEDLINE | ID: mdl-28559058

Subject(s)
Key words

2-D08; 2',3',4'-Trihydroxyflavone; Amyloid ß; Jaceosidin; Nobiletin; Quercetin; Transilitin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Amyloid beta-Peptides / Neuroprotective Agents / Flavones Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2017 Document type: Article Affiliation country: Australia Country of publication: Reino Unido

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