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A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action.
Campaner, Elena; Rustighi, Alessandra; Zannini, Alessandro; Cristiani, Alberto; Piazza, Silvano; Ciani, Yari; Kalid, Ori; Golan, Gali; Baloglu, Erkan; Shacham, Sharon; Valsasina, Barbara; Cucchi, Ulisse; Pippione, Agnese Chiara; Lolli, Marco Lucio; Giabbai, Barbara; Storici, Paola; Carloni, Paolo; Rossetti, Giulia; Benvenuti, Federica; Bello, Ezia; D'Incalci, Maurizio; Cappuzzello, Elisa; Rosato, Antonio; Del Sal, Giannino.
Affiliation
  • Campaner E; National Laboratory CIB (LNCIB), Area Science Park Padriciano, Trieste 34149, Italy.
  • Rustighi A; Department of Life Sciences, University of Trieste, Trieste 34127, Italy.
  • Zannini A; National Laboratory CIB (LNCIB), Area Science Park Padriciano, Trieste 34149, Italy.
  • Cristiani A; National Laboratory CIB (LNCIB), Area Science Park Padriciano, Trieste 34149, Italy.
  • Piazza S; Department of Life Sciences, University of Trieste, Trieste 34127, Italy.
  • Ciani Y; National Laboratory CIB (LNCIB), Area Science Park Padriciano, Trieste 34149, Italy.
  • Kalid O; National Laboratory CIB (LNCIB), Area Science Park Padriciano, Trieste 34149, Italy.
  • Golan G; National Laboratory CIB (LNCIB), Area Science Park Padriciano, Trieste 34149, Italy.
  • Baloglu E; Karyopharm Therapeutics, Newton, Massachusetts 02459, USA.
  • Shacham S; Karyopharm Therapeutics, Newton, Massachusetts 02459, USA.
  • Valsasina B; Karyopharm Therapeutics, Newton, Massachusetts 02459, USA.
  • Cucchi U; Karyopharm Therapeutics, Newton, Massachusetts 02459, USA.
  • Pippione AC; Nerviano Medical Sciences Srl, Nerviano 20014, Italy.
  • Lolli ML; Nerviano Medical Sciences Srl, Nerviano 20014, Italy.
  • Giabbai B; Department of Science and Drug Technology, University of Torino, Torino 10125, Italy.
  • Storici P; Department of Science and Drug Technology, University of Torino, Torino 10125, Italy.
  • Carloni P; Elettra Sincrotrone Trieste S.C.p.A., Area Science Park Basovizza, Trieste 34149, Italy.
  • Rossetti G; Elettra Sincrotrone Trieste S.C.p.A., Area Science Park Basovizza, Trieste 34149, Italy.
  • Benvenuti F; Computational Biomedicine, Institute for Advanced Simulation (IAS-5) and Institute of Neuroscience and Medicine (INM-9), Forschungszentrum Jülich, Jülich 52425, Germany.
  • Bello E; Computational Biomedicine, Institute for Advanced Simulation (IAS-5) and Institute of Neuroscience and Medicine (INM-9), Forschungszentrum Jülich, Jülich 52425, Germany.
  • D'Incalci M; Jülich Supercomputing Center (JSC), Forschungszentrum Jülich, Jülich 52425, Germany.
  • Cappuzzello E; Department of Oncology, Hematology and Stem Cell Transplantation, University Hospital Aachen, RWTH Aachen University, Aachen 52074, Germany.
  • Rosato A; International Centre for Genetic Engineering and Biotechnology (ICGEB), Area Science Park Padriciano, Trieste 34149, Italy.
  • Del Sal G; IRCCS-Mario Negri Institute for Pharmacological Research, Milano 20156, Italy.
Nat Commun ; 8: 15772, 2017 06 09.
Article in En | MEDLINE | ID: mdl-28598431
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enzyme Inhibitors / NIMA-Interacting Peptidylprolyl Isomerase / Lung Neoplasms / Antineoplastic Agents Limits: Animals / Female / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2017 Document type: Article Affiliation country: Italia Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enzyme Inhibitors / NIMA-Interacting Peptidylprolyl Isomerase / Lung Neoplasms / Antineoplastic Agents Limits: Animals / Female / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2017 Document type: Article Affiliation country: Italia Country of publication: Reino Unido