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mTOR signaling mediates resistance to tankyrase inhibitors in Wnt-driven colorectal cancer.
Mashima, Tetsuo; Taneda, Yoko; Jang, Myung-Kyu; Mizutani, Anna; Muramatsu, Yukiko; Yoshida, Haruka; Sato, Ayana; Tanaka, Noritaka; Sugimoto, Yoshikazu; Seimiya, Hiroyuki.
Affiliation
  • Mashima T; Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan.
  • Taneda Y; Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan.
  • Jang MK; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
  • Mizutani A; Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan.
  • Muramatsu Y; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
  • Yoshida H; Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan.
  • Sato A; Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan.
  • Tanaka N; Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan.
  • Sugimoto Y; Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan.
  • Seimiya H; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
Oncotarget ; 8(29): 47902-47915, 2017 Jul 18.
Article in En | MEDLINE | ID: mdl-28615517
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Signal Transduction / Drug Resistance, Neoplasm / Tankyrases / Wnt Proteins / TOR Serine-Threonine Kinases / Poly(ADP-ribose) Polymerase Inhibitors Limits: Humans Language: En Journal: Oncotarget Year: 2017 Document type: Article Affiliation country: Japón Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Signal Transduction / Drug Resistance, Neoplasm / Tankyrases / Wnt Proteins / TOR Serine-Threonine Kinases / Poly(ADP-ribose) Polymerase Inhibitors Limits: Humans Language: En Journal: Oncotarget Year: 2017 Document type: Article Affiliation country: Japón Country of publication: Estados Unidos