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Impact of the outcome of fresh blastocyst transfer on the subsequent frozen-thawed blastocyst transfer cycle.
El-Toukhy, Tarek; Kopeika, Julia Y; Beebeejaun, Yusuf; El Tokhy, Omar; Pundir, Jyotsna; Khalaf, Yacoub.
Affiliation
  • El-Toukhy T; Assisted Conception Unit, Guy's and St. Thomas' Hospital NHS Foundation Trust, London, UK. Electronic address: tarek.el-toukhy@gstt.nhs.uk.
  • Kopeika JY; Assisted Conception Unit, Guy's and St. Thomas' Hospital NHS Foundation Trust, London, UK.
  • Beebeejaun Y; Assisted Conception Unit, Guy's and St. Thomas' Hospital NHS Foundation Trust, London, UK.
  • El Tokhy O; Assisted Conception Unit, Guy's and St. Thomas' Hospital NHS Foundation Trust, London, UK.
  • Pundir J; Centre for Reproductive Medicine, St Bartholomew's Hospital, London, UK.
  • Khalaf Y; Assisted Conception Unit, Guy's and St. Thomas' Hospital NHS Foundation Trust, London, UK.
Reprod Biomed Online ; 35(5): 536-541, 2017 Nov.
Article in En | MEDLINE | ID: mdl-28754548
The objective of this observational study was to assess the influence of the outcome of fresh blastocyst transfer on the success rate of the subsequent sibling frozen-thawed blastocyst transfer (FBT) cycle. In total, 1639 FBT cycles were divided into two groups: Group A (n = 698) cycles in which a positive pregnancy test result was achieved and Group B (n = 941) cycles in which no pregnancy was achieved in the preceding fresh IVF cycle. Mean age at cryopreservation, basal FSH level, number of oocytes retrieved, number of embryos transferred in the fresh cycle and survival rate of the thawed blastocysts in the FBT cycle were comparable between the two groups. Although significantly more thawed blastocysts were transferred in the FBT cycles in Group B compared with Group A, the live birth rate in Group A was significantly higher compared with Group B. After adjusting for potentially confounding variables, the likelihood of a live birth after FBT was significantly higher when a pregnancy was achieved in the preceding fresh IVF cycle. Achieving a pregnancy after fresh blastocyst transfer is an independent factor influencing the outcome of the subsequent sibling FBT.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cryopreservation / Pregnancy Rate / Embryo Transfer / Live Birth / Freezing Type of study: Observational_studies Limits: Adult / Female / Humans / Pregnancy Language: En Journal: Reprod Biomed Online Journal subject: MEDICINA REPRODUTIVA Year: 2017 Document type: Article Country of publication: Países Bajos

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cryopreservation / Pregnancy Rate / Embryo Transfer / Live Birth / Freezing Type of study: Observational_studies Limits: Adult / Female / Humans / Pregnancy Language: En Journal: Reprod Biomed Online Journal subject: MEDICINA REPRODUTIVA Year: 2017 Document type: Article Country of publication: Países Bajos