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Preparation of Robust Metal-Free Magnetic Nanoemulsions Encapsulating Low-Molecular-Weight Nitroxide Radicals and Hydrophobic Drugs Directed Toward MRI-Visible Targeted Delivery.
Nagura, Kota; Takemoto, Yusa; Moronaga, Satori; Uchida, Yoshiaki; Shimono, Satoshi; Shiino, Akihiko; Tanigaki, Kenji; Amano, Tsukuru; Yoshino, Fumi; Noda, Yohei; Koizumi, Satoshi; Komatsu, Naoki; Kato, Tatsuhisa; Yamauchi, Jun; Tamura, Rui.
Affiliation
  • Nagura K; Graduate School of Human and Environmental Studies, Kyoto University, Yoshida Nihonmatsu-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
  • Takemoto Y; Graduate School of Human and Environmental Studies, Kyoto University, Yoshida Nihonmatsu-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
  • Moronaga S; Graduate School of Human and Environmental Studies, Kyoto University, Yoshida Nihonmatsu-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
  • Uchida Y; Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, 560-8531, Japan.
  • Shimono S; PRESTO (Japan) Science and Technology Agency, Kawaguchi, Saitama, 332-0012, Japan.
  • Shiino A; Graduate School of Human and Environmental Studies, Kyoto University, Yoshida Nihonmatsu-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
  • Tanigaki K; Biomedical MR Science Center, Shiga, University of Medical Science, Seta, Otsu, 520-2192, Japan.
  • Amano T; Shiga Medical Center Research Institute, Moriyama 5-4-30, Shiga, 524-8524, Japan.
  • Yoshino F; Department of Obstetrics and Gynecology, Shiga University of Medical Science, Seta, Otsu, 520-2192, Japan.
  • Noda Y; Department of Obstetrics and Gynecology, Shiga University of Medical Science, Seta, Otsu, 520-2192, Japan.
  • Koizumi S; Institute of Quantum Beam Science, Ibaraki University, Ibaraki, 316-8511, Japan.
  • Komatsu N; Institute of Quantum Beam Science, Ibaraki University, Ibaraki, 316-8511, Japan.
  • Kato T; Graduate School of Human and Environmental Studies, Kyoto University, Yoshida Nihonmatsu-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
  • Yamauchi J; Graduate School of Human and Environmental Studies, Kyoto University, Yoshida Nihonmatsu-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
  • Tamura R; Graduate School of Human and Environmental Studies, Kyoto University, Yoshida Nihonmatsu-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Chemistry ; 23(62): 15713-15720, 2017 Nov 07.
Article in En | MEDLINE | ID: mdl-28815766
With a view to developing a theranostic nanomedicine for targeted drug delivery systems visible by magnetic resonance (MR) imaging, robust metal-free magnetic nanoemulsions (mean particle size less than 20 nm) consisting of a biocompatible surfactant and hydrophobic, low molecular weight 2,2,5-trimethyl-5-(4-alkoxy)phenylpyrrolidine-N-oxyl radicals were prepared in pH 7.4 phosphate-buffered saline (PBS). The structure of the nanoemulsions was characterized by electron paramagnetic resonance spectroscopy, and dynamic light scattering and small-angle neutron-scattering measurements. The nanoemulsions showed high colloidal stability, low cytotoxicity, enough reduction resistance to excess ascorbic acid, and sufficient contrast enhancement in the proton longitudinal relaxation time (T1 ) weighted MR images in PBS in vitro (and preliminarily in vivo). Furthermore, the hydrophobic anticancer drug paclitaxel could be encapsulated inside the nanoparticles, and the resulting paclitaxel-loaded nanoemulsions were efficiently incorporated into HeLa cells to suppress cell growth.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Carriers / Paclitaxel / Magnetite Nanoparticles / Antineoplastic Agents, Phytogenic / Nitrogen Oxides Limits: Animals / Humans Language: En Journal: Chemistry Journal subject: QUIMICA Year: 2017 Document type: Article Affiliation country: Japón Country of publication: Alemania

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Carriers / Paclitaxel / Magnetite Nanoparticles / Antineoplastic Agents, Phytogenic / Nitrogen Oxides Limits: Animals / Humans Language: En Journal: Chemistry Journal subject: QUIMICA Year: 2017 Document type: Article Affiliation country: Japón Country of publication: Alemania