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Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants.
Gupta, Pulkit; Zhang, Zhifen; Sugiman-Marangos, Seiji N; Tam, John; Raman, Swetha; Julien, Jean-Phillipe; Kroh, Heather K; Lacy, D Borden; Murgolo, Nicholas; Bekkari, Kavitha; Therien, Alex G; Hernandez, Lorraine D; Melnyk, Roman A.
Affiliation
  • Gupta P; From Merck & Co., Inc., Kenilworth, New Jersey 07033.
  • Zhang Z; Molecular Medicine, The Hospital for Sick Children, Ontario M5G 0A4, Canada.
  • Sugiman-Marangos SN; the Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, and.
  • Tam J; Molecular Medicine, The Hospital for Sick Children, Ontario M5G 0A4, Canada.
  • Raman S; Molecular Medicine, The Hospital for Sick Children, Ontario M5G 0A4, Canada.
  • Julien JP; Molecular Medicine, The Hospital for Sick Children, Ontario M5G 0A4, Canada.
  • Kroh HK; Molecular Medicine, The Hospital for Sick Children, Ontario M5G 0A4, Canada.
  • Lacy DB; the Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, and.
  • Murgolo N; the Departments of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37212.
  • Bekkari K; the Departments of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37212.
  • Therien AG; From Merck & Co., Inc., Kenilworth, New Jersey 07033.
  • Hernandez LD; From Merck & Co., Inc., Kenilworth, New Jersey 07033.
  • Melnyk RA; From Merck & Co., Inc., Kenilworth, New Jersey 07033.
J Biol Chem ; 292(42): 17290-17301, 2017 10 20.
Article in En | MEDLINE | ID: mdl-28842504
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chondroitin Sulfate Proteoglycans / Bacterial Proteins / Bacterial Toxins / Clostridioides difficile / Glucosyltransferases / Membrane Proteins Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2017 Document type: Article Country of publication: Estados Unidos
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chondroitin Sulfate Proteoglycans / Bacterial Proteins / Bacterial Toxins / Clostridioides difficile / Glucosyltransferases / Membrane Proteins Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2017 Document type: Article Country of publication: Estados Unidos