Randomised controlled clinical trial of augmentation of the alveolar ridge using recombinant human bone morphogenetic protein 2 with hydroxyapatite and bovine-derived xenografts: comparison of changes in volume.
Br J Oral Maxillofac Surg
; 55(8): 822-829, 2017 Oct.
Article
in En
| MEDLINE
| ID: mdl-28864147
ABSTRACT
The aim of this randomised controlled clinical trial was to assess the early efficacy of bone morphogenetic protein-2 with hydroxyapatite granules (BMP-2/hydroxyapatite) on augmentation of the alveolar ridge, by comparing changes in volume with those associated with the use of an inorganic bovine-derived xenograft (BDX). We studied 20 patients who were divided into two groups using a table of random numbers, and BMP-2/hydroxyapatite and BDX were applied accordingly. Computed tomographic (CT) images and panoramic radiographs were obtained immediately after operation and four months later. CT images were reconstructed in three dimensions to measure volumetric changes, and linear measurements were made on panoramic images. The mean (SD) absorption rates for BMP-2/hydroxyapatite and BDX were 13.2 (8.8)% and 13.8 (20.5)%, respectively. While the mean value did not differ significantly between the two materials, the SD was higher in the BDX group than in the BMP-2/hydroxyapatite group. No clinically important complications occurred in either group. We conclude that both BMP-2/hydroxyapatite and BDX were effective in augmenting the alveolar ridge, but BMP-2/hydroxyapatite seemed to be more useful in complicated bone defects.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Biocompatible Materials
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Alveolar Bone Loss
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Transforming Growth Factor beta
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Bone Transplantation
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Durapatite
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Bone Morphogenetic Protein 2
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Alveolar Ridge Augmentation
Type of study:
Clinical_trials
Limits:
Adult
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Aged
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Aged80
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Animals
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Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
Br J Oral Maxillofac Surg
Year:
2017
Document type:
Article